Phenotypes associated with this allele

• Allele Symbol: olt
• Allele Name: oligotriche
• Allele ID: MGI:1856620
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	olt/olt	involves: C3H/HeJOrl	MGI:3702677
cx2	Plcd1^tm1Tta/olt	involves: 129P2/OlaHsd * C3H/HeJOrl * C57BL/6	MGI:3823245

Genotype
MGI:3702677

hm1

• Allelic Composition: olt/olt
• Genetic Background: involves: C3H/HeJOrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal hair follicle morphogenesis in olt/olt mice

reproductive system

reproductive system phenotype ( J:24774 )

N • female fertility is normal

abnormal reproductive system morphology ( J:24774 )

decreased testis weight ( J:12215 )

♂

abnormal gametogenesis ( J:24774 )

abnormal spermatogenesis ( J:12215 )

♂ • germ cell numbers are normal up to stage VII

♂ • significant drop in germ cell numbers after step 13

azoospermia ( J:24774 )

♂ • no spermatozoa in testis or epididymis

abnormal spermatid morphology ( J:12215 )

♂ • "homogenization resistant" testicular spermatids are significantly reduced in number

♂ • mature spermatids lack tail structures although manchettes do form

arrest of spermiogenesis ( J:18271 , J:30721 )

♂ • arrested at stage of elongating spermatids (acrosome phase) (J:18271)

♂ • aborted flagellum formation (J:18271)

♂ (J:30721)

male infertility ( J:24774 )

♂ • males are sterile

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:12215 )

N • testicular steroidogenesis is normal

decreased testis weight ( J:12215 )

♂

integument

integument phenotype ( J:142517 )

N • dorsal hair in normal anagen stage at day 15

N • normal vibrissae

abnormal hair growth ( J:142517 )

alopecia ( J:142517 )

• due to premature exit of anagen phase

retarded hair growth ( J:24774 )

• retarded growth of the ventral coat at 11 days

sparse hair ( J:24774 , J:142517 )

• sparse fur in adults (J:24774)

• females more affected than males (J:24774)

• conspicuously reduced in the lower ventral and medial femoral regions (J:142517)

• density of hair is slightly reduced dorsally (J:142517)

abnormal hair shaft morphology ( J:142517 )

• bent and coiled hair shafts in inguinal and medial femoral regions at postnatal day 15

• occasional dorsal hairs with bent and coiled hair shafts at postnatal day 15

abnormal hair cortex morphology ( J:142517 )

• incompletely keratinized

abnormal hair follicle morphology ( J:142517 )

abnormal hair follicle development ( J:142517 )

• no proliferation in narrow bulbs in the medial femoral region

• some apoptotic cells

decreased hair follicle number ( J:142517 )

• normal numbers at day 15

• become less abundant by 3 months of age

abnormal hair cycle catagen phase ( J:142517 )

• hair in inguinal and femoral regions is in catagen phase at postnatal day 15

abnormal epidermal layer morphology ( J:142517 )

• increased cell layers in regions with more pronounced alopecia

cellular

azoospermia ( J:24774 )

♂ • no spermatozoa in testis or epididymis

abnormal spermatid morphology ( J:12215 )

♂ • "homogenization resistant" testicular spermatids are significantly reduced in number

♂ • mature spermatids lack tail structures although manchettes do form

Genotype
MGI:3823245

cx2

• Allelic Composition: Plcd1^tm1Tta/olt
• Genetic Background: involves: 129P2/OlaHsd * C3H/HeJOrl * C57BL/6

reproductive system

reproductive system phenotype ( J:142517 )

N • male fertility is normal

integument

alopecia ( J:142517 )

abnormal epidermal layer morphology ( J:142517 )

• increased cell layers in regions with more pronounced alopecia