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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Paf
patchy fur
MGI:1856622
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Paf/Paf involves: C3H/HeSn MGI:3641056
ht2
Paf/Paf+ involves: C3H/HeSn MGI:3641050
ot3
Paf/Y C3H/HeSn-Paf/J MGI:3707592
ot4
Paf/Y involves: C3H/HeSn MGI:3641049


Genotype
MGI:3641056
hm1
Allelic
Composition
Paf/Paf
Genetic
Background
involves: C3H/HeSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paf mutation (1 available); any Paf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• coat of homozygous females is darker and shinier than heterozgous females
• homozygous females lose less juvenile hair than hemizygous males so hair is slightly less sparse than seen in a hemizygous mouse




Genotype
MGI:3641050
ht2
Allelic
Composition
Paf/Paf+
Genetic
Background
involves: C3H/HeSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paf mutation (1 available); any Paf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• heterozygous females have a variable striped or patchy coat, consistent with random inactivation
• coat appears to be striped black however dark color is the black base of hairs revealed by adjacent hair loss




Genotype
MGI:3707592
ot3
Allelic
Composition
Paf/Y
Genetic
Background
C3H/HeSn-Paf/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paf mutation (1 available); any Paf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Coat appearance of Paf/Y and Paf/Paf/ mice

reproductive system
• mating pairs involving Paf/Y males produce a female to male ratio, 62.1 : 38.9
• 12.1% of female offspring produced by Paf/Y males are 39, XO

cellular
• mating pairs involving Paf/Y males produce a female to male ratio, 62.1 : 38.9
• 12.1% of female offspring produced by Paf/Y males are 39, XO




Genotype
MGI:3641049
ot4
Allelic
Composition
Paf/Y
Genetic
Background
involves: C3H/HeSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Paf mutation (1 available); any Paf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

integument
• at 10 days the coat is darker than normal and shiny
• between 12 and 30 days of age hair loss is evident with progressive loss until only long guard hairs; no underfur
• guard hairs later become bristly, coat sparse with areas of hairlessness around the eyes, skin clearly visible through fur

cellular





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory