Phenotypes associated with this allele

• Allele Symbol: Sha
• Allele Name: shaven
• Allele ID: MGI:1856629
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sha/Sha	Not Specified	MGI:3606171
ht2	Sha/Sha^+	Not Specified	MGI:3606157

Genotype
MGI:3606171

hm1

• Allelic Composition: Sha/Sha
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:30772 )

• many mutants are at a competitive disadvantage and die before weaning

growth/size/body

abnormal postnatal growth ( J:4425 )

postnatal growth retardation ( J:4425 )

• mutants are not as competitive for food as normal sibs

• at 3 weeks of age mutant weight is half of controls; margin narrows with age but is always significant

integument

abnormal coat appearance ( J:30772 )

abnormal hair growth ( J:4425 , J:30772 )

• first pre-weaning hair coat does not appear (J:4425)

• by 14 days of age only a few short hairs appear on the head and feet; no hair appears on the trunk (J:4425)

• sparse hair growth on the trunk is noticeable between 28 and 34 days of age (J:4425)

sparse hair ( J:4425 )

• by 14 days of age only a few short hairs are noted on the head and feet; the trunk is hairless

abnormal hair cortex morphology ( J:4425 )

• cortex is thin or non-existent

abnormal hair medulla ( J:4425 )

• lacks normal ladder-like arrangement of septa and air-cells

abnormal hair medulla air spaces ( J:4425 )

• reduced in size, irregular, and filled with sudanophilic fluid

• clear and glassy when viewed by reflected light

abnormal hair medullary septa cells ( J:4425 )

• septa are thick and lack normal ladder-like arrangement

thin hair shaft ( J:4425 )

• hair is thin, uneven, and become entangled in the cells of the upper dermis

• abnormal keratinization of hair shafts is implicated

sparse vibrissae ( J:4425 )

• paucity noted at birth

wavy vibrissae ( J:4425 )

• short and wavy from birth on

abnormal hair cycle ( J:30772 )

Genotype
MGI:3606157

ht2

• Allelic Composition: Sha/Sha⁺
• Genetic Background: Not Specified

integument

abnormal coat appearance ( J:4425 , J:30772 )

• Background Sensitivity: hair sticks together and looks ruffled (J:4425)

greasy coat ( J:4425 , J:30772 )

• degree of greasiness is background related (J:4425)

abnormal hair medulla ( J:4425 )

• source of greasiness is sudanophilic fluid in hair medullae

abnormal hair medulla air spaces ( J:4425 )

• air spaces are smaller than normal and filled with sudanophilic fluid

curly vibrissae ( J:30772 )

wavy vibrissae ( J:4425 )

• less wavy than whiskers of homozygous mice