Analysis Tools
reproductive system
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• there are defects in chromosome pairing
• synaptonemal complex structure is abnormal
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• virtually all spermatogenic cells are in the pachytene stage
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small testis
(
J:9569
)
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• oocytes undergo maturation but can not be fertilized in vitro
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skeleton
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• the occurence of 12 rather than 13 ribs are the norm for the mutant mice
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rib fusion
(
J:9569
)
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• all mice have fusions of two or more ribs; as many as eight fusions may be observed
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• Background Sensitivity: abnormalities seen in the A/J background are normalized or less severe in a mixed C3H/HeBFeJ and C57BL/6J background
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• one or more caudal vertebrae are wedge-shaped
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• 21-26 caudal vertebrae are seen rather than the normal 28-30 range
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• all mice examined had fusions
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• 83% of mice examined had fusions
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• 92% of mice examined had fusions
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growth/size/body
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• Background Sensitivity: on this background mice are distinctly shorter than normal siblings a few days after birth; on other backgrounds bodies may be only slightly shorter
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limbs/digits/tail
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• one or more caudal vertebrae are wedge-shaped
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• 21-26 caudal vertebrae are seen rather than the normal 28-30 range
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kinked tail
(
J:9569
)
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• Background Sensitivity: obvious kinks are seen on this background but only a kink at the tip of the tail may be seen on other backgrounds
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endocrine/exocrine glands
small testis
(
J:9569
)
|
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cellular
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• there are defects in chromosome pairing
• synaptonemal complex structure is abnormal
|
|
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• virtually all spermatogenic cells are in the pachytene stage
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