Phenotypes associated with this allele

• Allele Symbol: ti
• Allele Name: tipsy
• Allele ID: MGI:1856635
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	ti/ti	involves: 101/H * C3H/HeH	MGI:2672790

Genotype
MGI:2672790

hm1

• Allelic Composition: ti/ti
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:295 )

• side-to-side swaying leads to reeling motion and falling

• however, mutant mice are able to swim normally

impaired righting response ( J:295 )

• when young mice are turned over their back, they take significantly longer than control mice to right themselves

impaired balance ( J:295 )

• although mutants show a normal postural reaction when suspended by the tail, they tend to land poorly when they are held by the tail and quickly lowered towards a solid surface

impaired limb coordination ( J:295 )

• as early as P6-P8, mutant mice flex and extend both hindlimbs together ("rabbit-gait") instead of moving the hindlimbs alternately

abnormal gait ( J:295 , J:64265 )

• as early as P6-P8, mutant mice flex and extend both hindlimbs together ("rabbit-gait") instead of moving the hindlimbs alternately (J:295)

• in severely affected mice, continuous rhythmic swaying leads to a reeling gait (J:295)

• unlike the swaying motion, the rabbit-like gait continues throughout life, but is often interspersed at all ages with a relatively normal locomotion (J:295)

• affected mice in the second week of life exhibit a "rabbit gait", i.e. they move both hindlimbs together while walking (J:64265)

weaving ( J:295 , J:64265 )

• at P10-P12, mutant mice display a variable tendency for the front part of the body to sway from side to side (J:295)

• severely affected mice exhibit an almost conitnuous rhythmic swaying; less affected mice show only an occasional side-to-side sway (J:295)

• mutants follow an S-shaped course, initially staggering in one direction and then in the other, and occasionally falling over on their side (J:295)

• the tendency to sway is lessened with advancing age, and disappears altogether in some adult mice (J:295)

• when placed down after being held up by the tail and gyrated, mutants display enhanced swaying in the direction of the rotation and back again (J:295)

reproductive system

reproductive system phenotype ( J:64265 )

N • both sexes are fertile

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:295 )

N • mutant mice are not deaf