Phenotypes associated with this allele

• Allele Symbol: Tim^T(4;17)3Lws
• Allele Name: translocation induced circling mutation 3 Lewis
• Allele ID: MGI:1856636
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tim^T(4;17)3Lws/Tim^+	involves: C57BL/6J * DBA/2J	MGI:3820250

Genotype
MGI:3820250

ht1

• Allelic Composition: Tim^T(4;17)3Lws/Tim⁺
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:10392 )

N • mice appear to live a normal lifespan

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:10392 )

• mice that are heterozygous for the translocation or have a karyotype of 41 chromosomes including Chr4, Chr17, and the small reciprocal translocation product 4¹⁷ are affected

impaired limb coordination ( J:10392 )

• disability is progressive

impaired swimming ( J:10392 )

• mice are able to orient themselves in water, but exhibit rolling and poor limb coordination and must be rescued

• older mice appear better able to keep their heads above water

head tossing ( J:10392 )

• becomes more pronounced as mice age

hyperactivity ( J:10392 )

circling ( J:10392 )

hearing/vestibular/ear

impaired hearing ( J:10392 )

• some mice do not respond to clicking

reproductive system

male infertility ( J:10392 )

♂ • many males are sterile

reduced fertility ( J:10392 )

• observed in both males and females

decreased litter size ( J:10392 )

• heterozygote x wild-type matings produce small litters

• average litter size produced by a male heterozygote x wild-type mating is 1.8 pups

• average litter size produced by a female heterozygote x wild-type mating is 3-5 pups

vision/eye

ciliary body hypoplasia ( J:52865 )

iris hypoplasia ( J:52865 )

cornea opacity ( J:10392 )

• younger animals exhibit a slight bilateral clouding which progresses to a white/opaque cornea by several months of age

abnormal lens epithelium morphology ( J:52865 )

anterior subcapsular cataract ( J:52865 )