Phenotypes associated with this allele

• Allele Symbol: Ad
• Allele Name: adult obesity and diabetes
• Allele ID: MGI:1856650
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ad/Ad	involves: Chr 7 marker stock * Wild stock	MGI:2654136
ht2	Ad/Ad^+	involves: Chr 7 marker stock * Wild stock	MGI:2654137

Genotype
MGI:2654136

hm1

• Allelic Composition: Ad/Ad
• Genetic Background: involves: Chr 7 marker stock * Wild stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased abdominal adipose tissue amount ( J:6095 )

♀ • the number of adipose cells increases in females but not in males, particularily in the abdominal, parametrial, and internal depots

increased total body fat amount ( J:6095 )

• carcass fat is increased 4-fold in males and 5.5-fold in females

increased fat cell size ( J:6095 )

• increased adipocyte size in both females and males

growth/size/body

obese ( J:6095 , J:6111 )

• animals weigh 50% more than wild-type at 6 months of age (J:6095)

• mice with the mutation can be classified between 4 and 6 months of age (J:6111)

liver/biliary system

abnormal liver morphology ( J:6095 )

• hypertrophic liver

homeostasis/metabolism

increased circulating insulin level ( J:6095 )

• 5-fold increase at 6 months of age

• however, glucose levels are normal

abnormal protein level ( J:6095 )

• mutants have an increased protein content

Genotype
MGI:2654137

ht2

• Allelic Composition: Ad/Ad⁺
• Genetic Background: involves: Chr 7 marker stock * Wild stock

adipose tissue

increased white adipose tissue amount ( J:6095 )

• the number of adipose cells increases in females but not in males

increased total body fat amount ( J:6095 )

increased fat cell size ( J:6095 )

• increased adipocyte size

abnormal abdominal fat pad morphology ( J:6095 )

• 4-fold increased fat mass in males, 8.7-fold increased fat mass in females

growth/size/body

obese ( J:6095 , J:6111 )

• animals weigh 50% more than wild-type (J:6095)

• at 4 months of age obesity is more severe in males than in females (J:6111)

liver/biliary system

abnormal liver morphology ( J:6095 )

• hypertrophic liver

homeostasis/metabolism

increased circulating insulin level ( J:6095 )

abnormal protein level ( J:6095 )

• mutants have an increased protein content