Phenotypes associated with this allele

• Allele Symbol: ag
• Allele Name: agitans
• Allele ID: MGI:1856653
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	ag/ag	Not Specified	MGI:4456971

Genotype
MGI:4456971

hm1

• Allelic Composition: ag/ag
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:266 )

• three months is the maximum life-span with many dying at 20-30 days of age

growth/size/body

decreased birth weight ( J:266 )

• some mice are underweight from birth compared with sib controls

cachexia ( J:266 )

• cause of death

postnatal growth retardation ( J:266 )

• recognized in the majority of mutants from 10 days onward

behavior/neurological

abnormal involuntary movement ( J:266 )

• mice make a series of motions made with one extremity fixed

tremors ( J:266 )

• generalized involuntary body movement

ataxia ( J:266 )

• evident when mice begin to walk

abnormal gait ( J:266 )

• initially mice walk hurredly, stiff-legged; after a month they walk with a duck-like waddle

hyperactivity ( J:266 )

• evident when mice begin to walk

nervous system

abnormal hippocampal mossy fiber morphology ( J:14888 )

abnormal cerebellum morphology ( J:14888 )

• lesions are obvious in mice by 21 days of age

Purkinje cell degeneration ( J:14888 )

decreased Purkinje cell number ( J:14888 )

abnormal spinal cord ventral horn morphology ( J:14888 )

• lesions are obvious in mice by 21 days of age, presenting as a general atrophy of the cells with significant degeneration of nuclei