Analysis Tools
pigmentation
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• hair that grows back at P21-P28 is darker than normal
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endocrine/exocrine glands
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• the mean diameters of sebaceous cell bodies and mean diameters of nuclei are significantly enlarged
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integument
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• the mean diameters of sebaceous cell bodies and mean diameters of nuclei are significantly enlarged
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• hair that grows back at P21-P28 is darker than normal
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• juvenile hair regrowth generally starts on the ventral surface at P21-P28
• in juvernile animals, the new coat of hair is rougher, darker, and slightly thinner than normal
• in breeding females, hair regrowth occurs shortly after nursing is terminated, but can be extended if the female becomes pregnant again before whe has weaned her litter
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• juvenile hair loss begins at P10-P15 above the eyes, or between the ears, proceeding back dorsally and laterally toward the tail
• the coat first thins on the neck, shoulders, forelegs, and under the chin
• as juvenile hair loss proceeds, the hair on the belly gets thinner and in some cases is entirely lost except for a few sparse scattered hairs
• hair is then lost on the thoracic dorsum, with some thinning on the rump, making the coat look scraggly
• a narrow strip of hair is retained along the dorsal midline
• some mice lose all hair except for pathches on the nose, tail, genitals, feet, and a few hairs scattered on the body
• other mice retain hair in pathces on the rump while some have only a slight thinning of hair
• although juvenile hair loss is severe in some animals it is not permanent, and all animals go through a regrowth stage at at P21-P28
• adult hair loss begins again at ~12 months of age, and is significantly different between males and nonpregnant females
• females show extensive hair loss during periods of pregnancy and nursing
• in breeding females, hair loss occurs at every pregnancy, beginning at ~8 days pregnancy and reaching it maximum at birth, with regrowth starting at the end of lactation unless the female is already pregnant again; the pattern of hair loss is similar to that of juvenile animals
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sparse hair
(
J:5122
)
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• hair that grows back at P21-P28 is thinner than normal
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rough coat
(
J:5122
)
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• hair that grows back at P21-P28 is rougher than normal
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