Analysis Tools
mortality/aging
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• mutant mice die in a state of anorexia and emaciation at ~P22
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behavior/neurological
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• failure to ingest sufficient amount of nutrients to sustain growth, indicating anorexia, starting at ~P5
• however, no deficiency in dietary or serum zinc (a frequent metabolic cause of anorexia) is observed
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• physiological and behavioral phenotypes appear to result from a suckling dysfunction
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• head and body tremors at P18 or later
• reduction in severity of head and body tremors following i.p. injection of the serotonin antagonist 5,7-dihydroxytryptamine at P20
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• headweaving at P18 or later
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abnormal gait
(
J:7689
)
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• uncoordinated gait at P18 or later
• reduction in severity of abnormal gait following i.p. injection of the serotonin antagonist 5,7-dihydroxytryptamine at P20
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hyperactivity
(
J:7689
)
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• hyperactivity at P18 or later
• reduction in hyperactivity following i.p. injection of the serotonin antagonist 5,7-dihydroxytryptamine at P20
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growth/size/body
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• significant reduction in body weight at P9
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• anorexic mutants are first recognized at ~P5 by a thinning of the neck and tail, and later by growth arrest and emaciation
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immune system
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• significant increase in thymus weight at P15 but not at P5
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small spleen
(
J:7689
)
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• beginning at ~P5, spleen size is reduced
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• significant reduction in spleen weight both at P5 and at P15
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pale spleen
(
J:7689
)
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• beginning at ~P5, spleen is pale in color
• however, total RBC count, hemoglobin, hematocrit, and mean corpuscular volume (MCV) are within normal range
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homeostasis/metabolism
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• significantly increased blood urea nitrogen levels relative to wild-type littermates at P15 (62.5 mg/dl vs 43.8 mg/dl, respectively)
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• significantly increased blood uric acid levels relative to wild-type littermates at P15 (4.6 mg/dl vs 1.2 mg/dl, respectively)
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hypoglycemia
(
J:7689
)
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• significantly decreased blood glucose levels relative to wild-type littermates at P15 (58 mg/dl vs 129 mg/dl, respectively)
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• significantly increased serum cholesterol levels relative to wild-type littermates at P15 (1.92 0.18 mg/ml vs 1.12 0.04 mg/ml, respectively)
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• significantly increased circulating alkaline phosphatase levels relative to wild-type littermates at P15 (1020 mU/ml vs 385 mU/ml, respectively)
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• significant hypothermia at ~P22, but not at P5, P10 or P15
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liver/biliary system
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• at P15, livers display a lacey appearance and are devoid of fat and glycogen
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nervous system
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• at P15, brains display an abundance of capillaries
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• significant increase in brain weight both at P5 and at P15
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cardiovascular system
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• at P15, brains display an abundance of capillaries
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hematopoietic system
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• significant increase in thymus weight at P15 but not at P5
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small spleen
(
J:7689
)
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• beginning at ~P5, spleen size is reduced
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• significant reduction in spleen weight both at P5 and at P15
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pale spleen
(
J:7689
)
|
• beginning at ~P5, spleen is pale in color
• however, total RBC count, hemoglobin, hematocrit, and mean corpuscular volume (MCV) are within normal range
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endocrine/exocrine glands
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• significant increase in thymus weight at P15 but not at P5
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