Phenotypes associated with this allele

• Allele Symbol: alp
• Allele Name: alopecia, recessive
• Allele ID: MGI:1856659
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	alp/alp	Not Specified	MGI:2654895

Genotype
MGI:2654895

hm1

• Allelic Composition: alp/alp
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:14855 )

• mutant mice display a ~3-fold increase in mortality rate

• general health and survival are severely diminished during the depilation period

growth/size/body

decreased body weight ( J:14855 )

• male mutants display a significant reduction in body weight starting at P21

• mutant females do not display a significant reduction in body weight until P30

• while alopecic males recover their normal weight at P60, females fail to do so until 3 months of age

abnormal postnatal growth ( J:14855 )

• postnatal growth is arrested during the depilation period

behavior/neurological

weakness ( J:14855 )

• alopecic mice are generally more frail than wild-type littermates

abnormal nursing ( J:14855 )

♀ • mutant females are unable to suckle their young

homeostasis/metabolism

impaired adaptive thermogenesis ( J:14855 )

• alopecic mice display increased cold sensitivity relative to wild-type littermates

integument

alopecia ( J:14855 )

• mutants begin to lose their fur at ~2 weeks of age, starting at the eye sockets and extending towards the back