Analysis Tools|
Allele Symbol Allele Name Allele ID |
Abl1m1 mutation 1 MGI:1856663 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• animals surviving to weaning are highly susceptible to infection
• only about 15% survive to 6 weeks of age
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• homozygous growth and development grossly normal through E17
• 75% of pups die within the first week after birth
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• young pups weigh 30-80% as much as controls
• low body weight persists through life
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• mature B cell population in bone marrow seems unaffected
• mature B cell numbers in peripheral blood and lymph nodes are normal
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• depleted by half to 2/3
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• severely reduced in number
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• depleted by half to 2/3 1n bone marrow
• depletion less severe in the spleen
• pre-B cell numbers normal in newborn spleen but become reduced over time
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• somewhat reduced CD4+ and CD8+ cells in peripheral blood
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• elevated CD4+ and CD8+ cells in the spleen
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• involuted thymi frequently found in mice dead at weaning
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• in mice dead at weaning
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• small thymus in many newborns
• 1/3 as many cells as in controls
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• early thymocyte numbers are sometimes reduced
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• round kidney shaped spleens
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• cell numbers in new born spleens about 50% of controls
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• white pulp depleted in mice showing extreme B cell depletion
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• animals surviving to weaning are highly susceptible to infection
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• slight shortening of the skull
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• many born with eyes open
• eyes often become damaged
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• involuted thymi frequently found in mice dead at weaning
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• in mice dead at weaning
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• small thymus in many newborns
• 1/3 as many cells as in controls
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• early thymocyte numbers are sometimes reduced
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• mature B cell population in bone marrow seems unaffected
• mature B cell numbers in peripheral blood and lymph nodes are normal
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• depleted by half to 2/3
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• severely reduced in number
|
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• depleted by half to 2/3 1n bone marrow
• depletion less severe in the spleen
• pre-B cell numbers normal in newborn spleen but become reduced over time
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• somewhat reduced CD4+ and CD8+ cells in peripheral blood
|
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• elevated CD4+ and CD8+ cells in the spleen
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• round kidney shaped spleens
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• cell numbers in new born spleens about 50% of controls
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• white pulp depleted in mice showing extreme B cell depletion
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• slight shortening of the skull
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• involuted thymi frequently found in mice dead at weaning
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• in mice dead at weaning
|
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• small thymus in many newborns
• 1/3 as many cells as in controls
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• early thymocyte numbers are sometimes reduced
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers
• reduced spleen response to anti-IgM
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• response of peripheral blood cells to lipopolysaccharide is about 38% of control response
• response of peripheral blood cells to "conA" is reduced to about 18% of control response
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• severe depletion becomes more common in mutants over 10 weeks of age
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• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age
• 77% of control levels overall
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• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age
• levels reduced overall to 67% of controls
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• almost completely depleted in bone marrow at 2 months of age
• overall levels at 63% of controls
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• severe depletion becomes more common in mutants over 10 weeks of age
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• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age
• 77% of control levels overall
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• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age
• levels reduced overall to 67% of controls
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• almost completely depleted in bone marrow at 2 months of age
• overall levels at 63% of controls
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• bone marrow cell response to Il7 is elevated in young animals and reduced in older ones
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• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers
• reduced spleen response to anti-IgM
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• calcium flux response to CD19 cross linking is absent
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• common lymphoid progenitors are dramatically reduced in number
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• "fraction A" pro-B-cells are dramatically reduced in number
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• calcium flux response to CD19 cross linking is absent
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• common lymphoid progenitors are dramatically reduced in number
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• "fraction A" pro-B-cells are dramatically reduced in number
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• calcium flux response to CD19 cross linking is absent
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• bone marrow cell response to Il7 is elevated
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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