Phenotypes associated with this allele

• Allele Symbol: Col1a1^Mov13
• Allele Name: Moloney leukemia virus 13
• Allele ID: MGI:1856671
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col1a1^Mov13/Col1a1^Mov13	C57BL/6-Col1a1^Mov13	MGI:3620078
hm2	Col1a1^Mov13/Col1a1^Mov13	involves: C57BL/6	MGI:3608493
ht3	Col1a1^Mov13/Col1a1^+	C57BL/6-Col1a1^Mov13	MGI:3620077
ht4	Col1a1^Mov13/Col1a1^+	involves: C57BL/6	MGI:3620112

Genotype
MGI:3620078

hm1

• Allelic Composition: Col1a1^Mov13/Col1a1^Mov13
• Genetic Background: C57BL/6-Col1a1^Mov13

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone ossification ( J:16630 )

• bone development and extent of ossification is markedly reduced when prospective bone-forming regions (parts of the lower jaw or central portion of the limbs of E12.5-13.5 embryos) are transplanted under the kidney capsule of adult wild-type hosts or onto chorioallantoic membrane of 8 day chick embryos

delayed bone ossification ( J:16630 )

• bone formation is initiated in two embryos that survive to E16, however bone development is retarded and does not progress to later stages of endochondrial ossification

Genotype
MGI:3608493

hm2

• Allelic Composition: Col1a1^Mov13/Col1a1^Mov13
• Genetic Background: involves: C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:6979 )

• most homozygous embryos are degenerated and bloodless at E13 - E14 with none seen at E15

embryo

embryonic growth arrest ( J:6979 )

• embryos stop developing at E11.5 - E12

Genotype
MGI:3620077

ht3

• Allelic Composition: Col1a1^Mov13/Col1a1⁺
• Genetic Background: C57BL/6-Col1a1^Mov13

pigmentation

abnormal coat/hair pigmentation ( J:6514 )

• between 6-8 weeks of age, many single, interspersed hairs turn white, indicating premature hair color change

integument

abnormal coat/hair pigmentation ( J:6514 )

• between 6-8 weeks of age, many single, interspersed hairs turn white, indicating premature hair color change

Genotype
MGI:3620112

ht4

• Allelic Composition: Col1a1^Mov13/Col1a1⁺
• Genetic Background: involves: C57BL/6

hearing/vestibular/ear

increased susceptibility to age-related hearing loss ( J:107045 )

• profound and progressive hearing loss with age

impaired hearing ( J:107045 )

• profound and progressive hearing loss with age

skeleton

abnormal compact bone morphology ( J:107045 )

• modulus of elasticity of cortical bone is lower

abnormal compact bone lamellar structure ( J:107045 )

• disorganized cortical bone, with bone cells not organized in a normal osteonal pattern and diorganization of collagen within the cortex

fragile skeleton ( J:107045 )

• exhibit a significant difference in the load deformation response of bones at failure, indicating brittle and fragile bones, however stiffness is normal

• modulus of elasticity of cortical bone is lower

integument

abnormal dermal layer morphology ( J:107045 )

• dermis contains unusually thin collagen fibers and collagen content in the dermis is reduced by about 50%

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteogenesis imperfecta type 1		DOID:0110334	OMIM:166200	J:107045