All Phenotypes Mlph<ln> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mlph^ln
leaden
MGI:1856674

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlph^ln/Mlph^ln	B6.Cg-Sgk3^fz H54 Mlph^ln/+ H54 +/J	MGI:3817194
hm2	Mlph^ln/Mlph^ln	C57BR	MGI:2680053
cx3	Mlph^ln/Mlph^ln Sgk3^fz/Sgk3^fz	C57BL/6J-Sgk3^fz Mlph^ln	MGI:3804905
cx4	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b	C57L/J	MGI:3052536
cx5	a/a Mlph^ln/Mlph^ln	involves: C57BL/J * C57BR	MGI:4454435
cx6	Mlph^ln/Mlph^ln Mreg^dsu/Mreg^dsu	involves: C57BR	MGI:3768124
cx7	l1Rk3/Mlph^ln	involves: C57L/J	MGI:2680054
cx8	Mc1r^e/Mc1r^e Mlph^ln/Mlph^ln	Not Specified	MGI:3689357
cx9	a/a Mlph^ln/Mlph^ln	Not Specified	MGI:5468335

Allelic Composition	Mlph^ln/Mlph^ln
Genetic Background	B6.Cg-Sgk3^fz H54 Mlph^ln/+ H54 +/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:141035 )

N	• mice exhibit wild-type iris pigmentation

Allelic Composition	Mlph^ln/Mlph^ln
Genetic Background	C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:17162 )

• melanin synthesis is normal but melanosomes transport is impaired resulting in a "leaden" coat color

integument

diluted coat color ( J:17162 )

• melanin synthesis is normal but melanosomes transport is impaired resulting in a "leaden" coat color

Allelic Composition	Mlph^ln/Mlph^ln Sgk3^fz/Sgk3^fz
Genetic Background	C57BL/6J-Sgk3^fz Mlph^ln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Sgk3^fz mutation (3 available); any Sgk3 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased bleeding time ( J:7327 )

• bleed time of 0.7 minutes after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls

Allelic Composition	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b
Genetic Background	C57L/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

abnormal melanocyte morphology ( J:5095 )

• results in clumping rather than even distribution of pigment during hair development

integument

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

Allelic Composition	a/a Mlph^ln/Mlph^ln
Genetic Background	involves: C57BL/J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanin granule distribution ( J:5346 )

• mice have clumped granules in the hair and skin

abnormal choroid melanin granule morphology ( J:5346 )

• granules tend to clump in the choroid but not in the retina

vision/eye

abnormal choroid melanin granule morphology ( J:5346 )

• granules tend to clump in the choroid but not in the retina

integument

abnormal hair follicle melanin granule distribution ( J:5346 )

• mice have clumped granules in the hair and skin

Allelic Composition	Mlph^ln/Mlph^ln Mreg^dsu/Mreg^dsu
Genetic Background	involves: C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:9309 )

• diluted coat color caused by the Mlph^ln allele is partially suppressed

integument

diluted coat color ( J:9309 )

• diluted coat color caused by the Mlph^ln allele is partially suppressed

Allelic Composition	l1Rk3/Mlph^ln
Genetic Background	involves: C57L/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
l1Rk3 mutation (1 available); any l1Rk3 mutation (1 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:71302 )

• phenotype was described as being similar to the original leaden allele

integument

diluted coat color ( J:71302 )

• phenotype was described as being similar to the original leaden allele

Allelic Composition	Mc1r^e/Mc1r^e Mlph^ln/Mlph^ln
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1r^e mutation (4 available); any Mc1r mutation (43 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:5110 )

• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1r^e mice

integument

diluted coat color ( J:5110 )

• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1r^e mice

Allelic Composition	a/a Mlph^ln/Mlph^ln
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

abnormal hair follicle melanocyte morphology ( J:12970 )

• pigment bearing cells have fewer and thinner dendritic processes than wild-type melanocytes

• abnormality of shape results in clumping of melanin granules

abnormal hair shaft melanin granule distribution ( J:12970 )

• melanin granules are clumped into large masses due to the shape of the melanocytes

diluted coat color ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

pigmentation

abnormal coat/hair pigmentation ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

abnormal hair follicle melanocyte morphology ( J:12970 )

• pigment bearing cells have fewer and thinner dendritic processes than wild-type melanocytes

• abnormality of shape results in clumping of melanin granules

abnormal hair shaft melanin granule distribution ( J:12970 )

• melanin granules are clumped into large masses due to the shape of the melanocytes

diluted coat color ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

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