All Phenotypes Mlph<ln> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mlph^ln
leaden
MGI:1856674

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlph^ln/Mlph^ln	B6.Cg-Sgk3^fz H54 Mlph^ln/+ H54 +/J	MGI:3817194
hm2	Mlph^ln/Mlph^ln	C57BR	MGI:2680053
cx3	Mlph^ln/Mlph^ln Sgk3^fz/Sgk3^fz	C57BL/6J-Sgk3^fz Mlph^ln	MGI:3804905
cx4	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b	C57L/J	MGI:3052536
cx5	a/a Mlph^ln/Mlph^ln	involves: C57BL/J * C57BR	MGI:4454435
cx6	Mlph^ln/Mlph^ln Mreg^dsu/Mreg^dsu	involves: C57BR	MGI:3768124
cx7	l1Rk3/Mlph^ln	involves: C57L/J	MGI:2680054
cx8	Mc1r^e/Mc1r^e Mlph^ln/Mlph^ln	Not Specified	MGI:3689357
cx9	a/a Mlph^ln/Mlph^ln	Not Specified	MGI:5468335

Allelic Composition	Mlph^ln/Mlph^ln
Genetic Background	B6.Cg-Sgk3^fz H54 Mlph^ln/+ H54 +/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:141035 )

N	• mice exhibit wild-type iris pigmentation

Allelic Composition	Mlph^ln/Mlph^ln
Genetic Background	C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:17162 )

• melanin synthesis is normal but melanosomes transport is impaired resulting in a "leaden" coat color

integument

diluted coat color ( J:17162 )

• melanin synthesis is normal but melanosomes transport is impaired resulting in a "leaden" coat color

Allelic Composition	Mlph^ln/Mlph^ln Sgk3^fz/Sgk3^fz
Genetic Background	C57BL/6J-Sgk3^fz Mlph^ln

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Sgk3^fz mutation (3 available); any Sgk3 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased bleeding time ( J:7327 )

• bleed time of 0.7 minutes after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls

Allelic Composition	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b
Genetic Background	C57L/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (465 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

abnormal melanocyte morphology ( J:5095 )

• results in clumping rather than even distribution of pigment during hair development

integument

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

Allelic Composition	a/a Mlph^ln/Mlph^ln
Genetic Background	involves: C57BL/J * C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (465 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal hair follicle melanin granule distribution ( J:5346 )

• mice have clumped granules in the hair and skin

abnormal choroid melanin granule morphology ( J:5346 )

• granules tend to clump in the choroid but not in the retina

vision/eye

abnormal choroid melanin granule morphology ( J:5346 )

• granules tend to clump in the choroid but not in the retina

integument

abnormal hair follicle melanin granule distribution ( J:5346 )

• mice have clumped granules in the hair and skin

Allelic Composition	Mlph^ln/Mlph^ln Mreg^dsu/Mreg^dsu
Genetic Background	involves: C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:9309 )

• diluted coat color caused by the Mlph^ln allele is partially suppressed

integument

diluted coat color ( J:9309 )

• diluted coat color caused by the Mlph^ln allele is partially suppressed

Allelic Composition	l1Rk3/Mlph^ln
Genetic Background	involves: C57L/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
l1Rk3 mutation (1 available); any l1Rk3 mutation (1 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:71302 )

• phenotype was described as being similar to the original leaden allele

integument

diluted coat color ( J:71302 )

• phenotype was described as being similar to the original leaden allele

Allelic Composition	Mc1r^e/Mc1r^e Mlph^ln/Mlph^ln
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1r^e mutation (4 available); any Mc1r mutation (44 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:5110 )

• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1r^e mice

integument

diluted coat color ( J:5110 )

• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1r^e mice

Allelic Composition	a/a Mlph^ln/Mlph^ln
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (465 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

abnormal hair follicle melanocyte morphology ( J:12970 )

• pigment bearing cells have fewer and thinner dendritic processes than wild-type melanocytes

• abnormality of shape results in clumping of melanin granules

abnormal hair shaft melanin granule distribution ( J:12970 )

• melanin granules are clumped into large masses due to the shape of the melanocytes

diluted coat color ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

pigmentation

abnormal coat/hair pigmentation ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

abnormal hair follicle melanocyte morphology ( J:12970 )

• pigment bearing cells have fewer and thinner dendritic processes than wild-type melanocytes

• abnormality of shape results in clumping of melanin granules

abnormal hair shaft melanin granule distribution ( J:12970 )

• melanin granules are clumped into large masses due to the shape of the melanocytes

diluted coat color ( J:12970 )

• this genotype is indistinguishable from homozygous nonagouti, Myo5a^d mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24