Analysis Tools
growth/size/body
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• mutant mice show a postnatal growth retardation which becomes prominent from P10 to P30, and persists throughout life but is less marked in older individuals
• however, a normal body size is noted at birth
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endocrine/exocrine glands
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• the mutant sebaceous glands are larger than normal in the resting (telogen) phase
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vision/eye
integument
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• the mutant sebaceous glands are larger than normal in the resting (telogen) phase
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• mutant hair is shed by ~30 days of age
• a new hair cycle days starts at 45 days but hair is thin and is soon shed
• affected mice are naked by 6 months of age
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• unlike wild-type mice which display small tiny hairs on the head, neck and back at P4 and a fine coat of hair by P10, mutants display the first signs of small fine hairs at ~P12, with a delay of ~ 8 days
• these tiny hairs remain on the body for another 12-15 days and are shed by ~P30
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• mutants are strikingly hairless by 6 months of age
• only very few mutants have small hairs on the head and back which drop off and redevelop on cycles
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short hair
(
J:291
)
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• the first hairs on the body appear at P13-P14 and are thin, tiny, and of poor quality
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sparse hair
(
J:291
)
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• by P21-P22, the mutant skin is covered with fine sparse hair until ~P30, when hair is lost
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• mutant hairs are thin with an irregular arrangement of air cells in the internal structure
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thin hair shaft
(
J:291
)
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• the hypodermis of mutant, but not wild-type, mice increases in thickness with hair growth
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• mutant follicles contain keratinized globular masses, suggesting defective formation of the straight medullated hair
• this abnormality persists in all hair cycles
• however, the number of hair follicles remains normal
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• at P4, yellow keratinized masses are observed in the bulbs of the follicles, suggesting that the entire keratinization of hair occurs in the bulb of the follicle
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• at birth, mutants mice are readily recognizable by the absence of vibrissae and other sensory hairs on the face
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• the first hairs on the body appear at P13-P14 and disappear by ~P30
• the hairs in the second hair cycle appear at ~P45 and again disappear within 10 days
• in mutant mice, the hairs in the first hair cycle do not display the four different normal types of hairs (guard hairs, awls, auchenes, and zig zags)
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• the progess of hair development in the anagen stages IV, V and VI is delayed
• in contrast, the catagen and telogen stages appear unaffected
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• the skin in older mutant mice remains smooth instead of being thickened or folded
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• the dermis of mutant, but not wild-type, mice increases in thickness with hair growth
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thick epidermis
(
J:291
)
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• the epidermis of mutant, but not wild-type, mice increases in thickness with hair growth
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