Phenotypes associated with this allele

• Allele Symbol: Zic3^Bn
• Allele Name: bent tail
• Allele ID: MGI:1856679
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zic3^Bn/Zic3^Bn	BNT/LeJ	MGI:2657283
ht2	Zic3^Bn/Zic3^+	BNT/LeJ	MGI:2657281
ot3	Zic3^Bn/0	involves: BNT/LeJ * C57BL/6J	MGI:7378518

Genotype
MGI:2657283

hm1

• Allelic Composition: Zic3^Bn/Zic3^Bn
• Genetic Background: BNT/LeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:13124 , J:14983 )

♀ (J:13124)

♀ (J:14983)

prenatal lethality, incomplete penetrance ( J:63168 )

♀ • approximately 1/4 of animals are lost due to early lethality

craniofacial

increased cranium width ( J:5776 )

♀ • the skull is slightly wider than normal

abnormal neurocranium morphology ( J:5776 )

♀

abnormal interfrontal bone morphology ( J:5776 )

♀ • interfrontal bone is often present

cranioschisis ( J:5776 , J:63168 )

♀ • variable penetrance (J:5776)

♀ (J:63168)

growth/size/body

postnatal growth retardation ( J:63168 )

♀ • in the most severely affected animals

situs ambiguus ( J:62608 )

♀ • abnormal organ position, found in more than 50% of Bn/Y males and 38% of carrier females

limbs/digits/tail

decreased caudal vertebrae number ( J:63168 )

♀ • fewer and smaller caudal vertebrae than normal; more severe than heterozygous female

short tail ( J:13124 , J:14983 , J:62608 , J:63168 )

♀ (J:13124)

♀ (J:14983)

♀ (J:62608)

♀ (J:63168)

kinked tail ( J:13124 , J:14983 , J:62608 , J:63168 )

♀ (J:13124)

♀ (J:14983)

♀ (J:62608)

♀ (J:63168)

reproductive system

reduced fertility ( J:13124 , J:14983 , J:63168 )

♀ • number of affected offspring is lower than expected (J:13124)

♀ (J:14983)

♀ (J:63168)

skeleton

increased cranium width ( J:5776 )

♀ • the skull is slightly wider than normal

abnormal neurocranium morphology ( J:5776 )

♀

abnormal interfrontal bone morphology ( J:5776 )

♀ • interfrontal bone is often present

cranioschisis ( J:5776 , J:63168 )

♀ • variable penetrance (J:5776)

♀ (J:63168)

decreased caudal vertebrae number ( J:63168 )

♀ • fewer and smaller caudal vertebrae than normal; more severe than heterozygous female

nervous system

open neural tube ( J:5776 , J:63168 )

♀ • variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)

♀ (J:63168)

exencephaly ( J:5776 , J:63168 )

♀ • variable penetrance (J:5776)

♀ (J:63168)

embryo

open neural tube ( J:5776 , J:63168 )

♀ • variable penetrance, in the sacral region; omphalocele and ventral midline closure defects noted in small numbers of embryos (J:5776)

♀ (J:63168)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:5776 , J:13124 , J:14983 , J:62608 , J:63168

Genotype
MGI:2657281

ht2

• Allelic Composition: Zic3^Bn/Zic3⁺
• Genetic Background: BNT/LeJ

growth/size/body

situs ambiguus ( J:62608 )

♀ • abnormal organ position, found in more than 50% of Bn/Y males and 38% of carrier females

limbs/digits/tail

decreased caudal vertebrae number ( J:63168 )

♀ • fewer caudal vertebrae than normal

short tail ( J:13124 , J:14983 , J:63168 )

♀ • variable and milder severity compared to homozygous females and hemizygous males (J:13124)

♀ (J:14983)

♀ (J:63168)

kinked tail ( J:13124 , J:14983 , J:63168 )

♀ • one or more bends (J:13124)

♀ (J:14983)

♀ (J:63168)

skeleton

decreased caudal vertebrae number ( J:63168 )

♀ • fewer caudal vertebrae than normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:63168 , J:62608 , J:14983 , J:13124 , J:5776

Genotype
MGI:7378518

ot3

• Allelic Composition: Zic3^Bn/0
• Genetic Background: involves: BNT/LeJ * C57BL/6J

behavior/neurological

behavior/neurological phenotype ( J:101328 )

♂N • mice exhibit normal behavior on the rotating rod, forced swimming, Morris Water Maze, and elevated-plus maze tests

abnormal horizontal vestibuloocular reflex ( J:101328 )

♂ • mice exhibit a reduction in gains of the horizontal vestibulo-ocular and optokinetic reflex tests as well as depressed adaptability of horizontal optokinetic reflex compared with wild-type mice

♂ • however, there is no difference in the phases

impaired coordination ( J:101328 )

♂ • shorter retention time in the wire-hanging test

♂ • however, grip strength is normal

hypoactivity ( J:101328 )

♂ • reduced horizontal motor activity in an open space

hearing/vestibular/ear

abnormal horizontal vestibuloocular reflex ( J:101328 )

♂ • mice exhibit a reduction in gains of the horizontal vestibulo-ocular and optokinetic reflex tests as well as depressed adaptability of horizontal optokinetic reflex compared with wild-type mice

♂ • however, there is no difference in the phases

nervous system

abnormal cerebellar hemisphere morphology ( J:101328 )

♂ • reduced size of the parafloccus-floccus complex

abnormal cerebellum vermis lobule III morphology ( J:101328 )

♂ • severely reduced size of the anterior central lobe

abnormal cerebellum vermis lobule V morphology ( J:101328 )

♂ • reduced size

cerebellum vermis hypoplasia ( J:101328 )

♂ • marked in the anterior lobe (lobules I-V) and in the uvula (IX) and nodule (X)

♂ • however, folial patterning is normal