All Phenotypes Bld MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bld/Bld	involves: BALB/cCi	MGI:2657303
ht2	Bld/Bld⁺	involves: BALB/cCi	MGI:2657304

Allelic Composition	Bld/Bld
Genetic Background	involves: BALB/cCi

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:5076 , J:6141 )

• embryos die at E7 (J:5076)

• lethality occurs before E8, resulting from failure of the trophectoderm to fuse to the uterus (J:6141)

growth/size/body

embryonic growth retardation ( J:6141 )

• observed by E6

decreased embryo size ( J:6141 )

• E6 mutants are shorter and smaller than controls

embryo

abnormal endoderm development ( J:6141 )

• endoderm cells right before E7 do not show normal differentiation into columnar, cuboidal and squamosal epithelium

abnormal mesoderm development ( J:6141 )

• mesoderm is seen occasionally but is not always present

embryonic growth retardation ( J:6141 )

• observed by E6

decreased embryo size ( J:6141 )

• E6 mutants are shorter and smaller than controls

abnormal primitive streak formation ( J:6141 )

• do not form a complete primitive streak

abnormal extraembryonic tissue morphology ( J:6141 )

abnormal visceral yolk sac morphology ( J:6141 )

• endodermal cells invade the yolk sac

abnormal extraembryonic endoderm formation ( J:6141 )

• endodermal cells, particularly in the proximal part of the extraembryonic region, are enlarged, disorganized and become polyploidy

reproductive system

abnormal embryo implantation ( J:6141 )

• trophoectoderm fails to fuse with the uterine decidua and the ectoplacental cone is not in contact with uterine tissue

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:6008 )

• Background Sensitivity: genetic background determines viability of heterozygotes

vision/eye

increased incidence of corneal inflammation ( J:5076 )

• an inflammatory response is observed in thickend corneas, with an accumulation of white blood cells under the outer epithelium

abnormal eye morphology ( J:5076 )

• within a day or two of birth, a noticeable exudate appears in the eye resulting in the formation of a scab over the eye and damage to the eye when the scab drops off

• variable level of opacity in the eye

optic nerve hypoplasia ( J:5076 )

• optic nerves of blind eyes are smaller

abnormal cornea morphology ( J:5076 )

• corneal damage; within minutes after birth, the cornea becomes dry and the lids attach firmly to the edges of the cornea

cornea vascularization ( J:5076 )

• when the eye is extremely opaque, blood vessels are seen growing into the corneal tissue

cornea epithelium hyperplasia ( J:5076 )

• hyperplasia of the outer epithelium

increased cornea thickness ( J:5076 )

• corneas are often thickened, sometimes by as much as 6-fold

cornea opacity ( J:5076 )

• at 25-30 days of age, part of the cornea may be opaque

abnormal lens morphology ( J:5076 )

• lens may be missing or may be present with a few to many vacuoles

• sometimes the lens is misshapen

fused cornea and lens ( J:5076 )

• sometimes the lens is firmly attached to the cornea

lens vacuoles ( J:5076 )

• lens may be present with a few to many vacuoles

aphakia ( J:5076 )

• lens may be missing

cataract ( J:5076 )

• incomplete penetrance

microphthalmia ( J:5076 )

• opaque eyes are typicall smaller than controls

eyelids open at birth ( J:5076 )

• Background Sensitivity: unilateral, bilateral occurrence is variable and can be enhanced on certain backgrounds

abnormal retina morphology ( J:5076 )

• if the lens is absent, the retina may be collapsed or folded

• when lens is present, the most common defect is rosette formation

retina degeneration ( J:5076 )

• most often the retina shows some deteriorative change

retina fold ( J:5076 )

• if the lens is absent, the retina may be folded

blindness ( J:5076 )

• in a few cases, mutants become blind after weaning; blindness can be either uni- or bilateral

immune system