Analysis Tools
behavior/neurological
|
• mice exhibit postural asymmetry
|
hyperactivity
(
J:87399
)
|
• mice exhibit general hyperactivity and hyperactivity in response to sensory stimuli
• however, treatment with clozapine or olanzapine reduces hyperactivity
|
|
• circling behavior is first observed at 1-2 weeks of age
(J:10932)
• circling behavior is almost continuous throughout the night and in response to stress (e.g. hand clapping) during daytime (J:10932)
(J:10932)
• both net rotations (defined as full turns in preferred direction minus full turns in non-preferred direction) and percentage preference (defined as full turns in preferred direction over total full turns x 100) are significantly increased during spontaneous nocturnal (16 hr) circling
(J:10932)
• circling behavior is accompanied by a decrease in rearing, sniffling and grooming compared to wild-type mice
(J:87399)
• circling is observed in an open field and in home cages
(J:87399)
• however, treatment with clozapine or olanzapine reduces circling behavior
(J:87399)
|
|
• mice preferentially circle to the left
|
nervous system
|
• by 1500% compared to in wild-type mice
|
|
• by 60% compared to in wild-type mice
|
|
• the dopamine D2 receptor binding sites in the striata of circling mice are increased by ~31% relative to normal heterozygous littermates
(J:10932)
• myelinated axons are decreased 70% in the striatum compared to in wild-type mice
(J:87399)
• however, the number of NOS and cholinergic interneurons in the striatum is normal
(J:87399)
|
|
• fewer fine, individual myelinated fibers are present in the lateral quadrants of the caudate-putamen compared to in wild-type mice especially near the ventricular ependyma
|
hearing/vestibular/ear
| N |
• no hearing loss or inner ear defects are observed in spite of circling behavior
• no other behaviors characteristic of the shaker/waltzer syndrome are observed
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:87399 | |
