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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		th49
t, Harwell 49
MGI:1856742
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nme3tm1Bgh/Nme3+
th49/t+ 		involves: 129S1/Sv MGI:5319401
cx2
 		Fgd2tm1Bgh/Fgd2+
th49/t+ 		involves: BTBR MGI:3700705
cx3
 		th49/t+
Tg(Ace-Tiam2)C1L1Bgh/0 		involves: C57BL/6J MGI:6360723
cx4
 		th49/t+
Tg(Ace-Tiam2)C1L2Bgh/0 		involves: C57BL/6J MGI:6360724


Genotype
MGI:5319401
cx1
Allelic
Composition		 Nme3tm1Bgh/Nme3+
th49/t+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nme3tm1Bgh mutation (0 available); any Nme3 mutation (10 available)
th49 mutation (1 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:183481 )
• mice exhibit increased transmission of the t-haplotype compared with wild-type mice




Genotype
MGI:3700705
cx2
Allelic
Composition		 Fgd2tm1Bgh/Fgd2+
th49/t+
Genetic
Background		 involves: BTBR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgd2tm1Bgh mutation (0 available); any Fgd2 mutation (34 available)
th49 mutation (1 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:117419 )
• mice transmitted the th49 allele to only 35% of their offspring compared to a transmission rate of 47% for mice without the Fgd2 mutant allele




Genotype
MGI:6360723
cx3
Allelic
Composition		 th49/t+
Tg(Ace-Tiam2)C1L1Bgh/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ace-Tiam2)C1L1Bgh mutation (0 available)
th49 mutation (1 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:273736 )
• mice exhibit reduced transmission of th49 compared with wild-type mice




Genotype
MGI:6360724
cx4
Allelic
Composition		 th49/t+
Tg(Ace-Tiam2)C1L2Bgh/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ace-Tiam2)C1L2Bgh mutation (0 available)
th49 mutation (1 available); any t mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:273736 )
• mice exhibit reduced transmission of th49 compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory