Phenotypes associated with this allele

• Allele Symbol: Dab1^scm
• Allele Name: scrambler
• Allele ID: MGI:1856801
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^scm/Dab1^scm	involves: C3H * C57BL/6J	MGI:3784586
hm2	Dab1^scm/Dab1^scm	involves: C3HeB/FeJ * DC/Le	MGI:4353813

Genotype
MGI:3784586

hm1

• Allelic Composition: Dab1^scm/Dab1^scm
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal retina rod bipolar cell morphology ( J:71970 )

• density of cells is decreased, indicating a decreased number of rod bipolar cells compared to controls

vision/eye

abnormal retina rod bipolar cell morphology ( J:71970 )

• density of cells is decreased, indicating a decreased number of rod bipolar cells compared to controls

abnormal retina inner nuclear layer morphology ( J:71970 )

• density of synaptic terminals is decreased compared to controls

abnormal cone electrophysiology ( J:71970 )

• cone mediated-responses are reduced in amplitude and delayed in mutants; difference compared to wild-type cone function is not as great as differences in rod function

abnormal rod electrophysiology ( J:71970 )

• amplitude of a-wave of ERG in response to bright light flash is smaller than in controls while the b-wave is significantly reduced

• oscillatory potentials (OPs) are reduced in amplitude

Genotype
MGI:4353813

hm2

• Allelic Composition: Dab1^scm/Dab1^scm
• Genetic Background: involves: C3HeB/FeJ * DC/Le

Cerebellum size is reduced in Dab1^scm/Dab1^scm mice

mortality/aging

decreased survivor rate ( J:37166 )

• mice that do survive live a normal lifespan

postnatal lethality ( J:37166 )

• unless litters are culled to reduce competition for food, a significant number of mutants die before weaning

growth/size/body

decreased body size ( J:37166 )

• size difference begins to show after 15 days of age

• mutant mice frequently cannot be weaned until 5-6 weeks of age; culling some normal siblings prior to weaning can assure survivability of mutant mice

behavior/neurological

tremors ( J:37166 )

• mice exhibit a whole-body tremor

abnormal motor coordination/balance ( J:37166 )

• phenotype is consistent throughout life

abnormal gait ( J:37166 )

reproductive system

male infertility ( J:37166 )

♂

nervous system

abnormal cerebellar foliation ( J:37166 )

• this layer is not seen or reduced

abnormal hippocampus morphology ( J:37166 )

• this area is severely disorganized

• the pyramidal cells are aligned in two or more wavy rows rather than in a single curving row

abnormal dentate gyrus morphology ( J:37166 )

• neurons are randomly scattered

abnormal hippocampus pyramidal cell morphology ( J:37166 )

abnormal cerebral cortex morphology ( J:37166 )

• this area lacks its normal six layered structure

• large pyramidal cells and small granule cells are scattered rather than segregated into specific layers

abnormal stratification in cerebral cortex ( J:37166 )

abnormal cerebellar Purkinje cell layer ( J:37166 )

• a layer is not seen; Purkinje cells are scattered throughout the granule layer and beneath it

small cerebellum ( J:37166 )

• greatly reduced in size compared with normal littermates