Phenotypes associated with this allele

• Allele Symbol: 4930453N24Rik^din
• Allele Name: dense incisors
• Allele ID: MGI:1856802
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	4930453N24Rik^din/4930453N24Rik^din	B6C3Fe a/a-4930453N24Rik^din/J	MGI:3047683

Genotype
MGI:3047683

hm1

• Allelic Composition: 4930453N24Rik^din/4930453N24Rik^din
• Genetic Background: B6C3Fe a/a-4930453N24Rik^din/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:32738 )

• most die before 5 months of age

skeleton

abnormal incisor morphology ( J:32738 )

• continued dentin formation after arrested incisor eruption occludes pulp chamber creating a dense incisor

failure of tooth eruption ( J:32738 )

• incisors begin to erupt but cease erupting after initial penetration of the oral epithelium

• molar eruption is unaffected

abnormal dentin morphology ( J:32738 )

• incisors show increased dentin thickness in older mice

abnormal dentin development ( J:32738 )

• continued dentin formation after arrested tooth eruption occludes pulp chamber creating a dense incisor

malocclusion ( J:32738 )

• failure of continued incisor eruption produces an open bite anteriorly, rendering these teeth useless for chewing and gnawing

pigmentation

abnormal coat/hair pigmentation ( J:32738 )

• the ventral coat is lighter resembling a^t or A^w;white feet and tail tip observed; yellow hair absent from ears

irregular coat pigmentation ( J:32738 )

• abnormal dorsoventral pigment pattern resembles a^t and A^w

craniofacial

abnormal incisor morphology ( J:32738 )

• continued dentin formation after arrested incisor eruption occludes pulp chamber creating a dense incisor

failure of tooth eruption ( J:32738 )

• incisors begin to erupt but cease erupting after initial penetration of the oral epithelium

• molar eruption is unaffected

abnormal dentin morphology ( J:32738 )

• incisors show increased dentin thickness in older mice

abnormal dentin development ( J:32738 )

• continued dentin formation after arrested tooth eruption occludes pulp chamber creating a dense incisor

malocclusion ( J:32738 )

• failure of continued incisor eruption produces an open bite anteriorly, rendering these teeth useless for chewing and gnawing

small ears ( J:32738 )

growth/size/body

abnormal incisor morphology ( J:32738 )

• continued dentin formation after arrested incisor eruption occludes pulp chamber creating a dense incisor

failure of tooth eruption ( J:32738 )

• incisors begin to erupt but cease erupting after initial penetration of the oral epithelium

• molar eruption is unaffected

abnormal dentin morphology ( J:32738 )

• incisors show increased dentin thickness in older mice

abnormal dentin development ( J:32738 )

• continued dentin formation after arrested tooth eruption occludes pulp chamber creating a dense incisor

malocclusion ( J:32738 )

• failure of continued incisor eruption produces an open bite anteriorly, rendering these teeth useless for chewing and gnawing

small ears ( J:32738 )

postnatal growth retardation ( J:32738 )

• mean body weight increasingly differs from normal littermates after the first postnatal week and is not caused by abnormal dentition

hearing/vestibular/ear

small ears ( J:32738 )

integument

abnormal coat/hair pigmentation ( J:32738 )

• the ventral coat is lighter resembling a^t or A^w;white feet and tail tip observed; yellow hair absent from ears

irregular coat pigmentation ( J:32738 )

• abnormal dorsoventral pigment pattern resembles a^t and A^w