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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gdf5brp
brachypod Japan
MGI:1856810
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gdf5brp/Gdf5brp involves: NC MGI:2658810


Genotype
MGI:2658810
hm1
Allelic
Composition
Gdf5brp/Gdf5brp
Genetic
Background
involves: NC
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf5brp mutation (0 available); any Gdf5 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• homozygotes show striking abnormalities of the autopod (manus and pes)
• homozygotes exhibit brachypodism, as shown by X-ray photographs of the hindlimbs
• either the middle or proximal phalanx is usually lost
• mutant phalanges excluding the terminal one appear underdeveloped
• homozygotes show a modest reduction in the stylopod and zeugopod relative to wild-type controls
• homozygotes display shortening of all four limbs

growth/size/body
• at birth, homozygotes display reduced body weights relative to heterozygous controls
• homozygotes display a progressive reduction in body weight relative to heterozygous controls (J:31930)
• at P40 and P60, homozygotes of both sexes are significantly lighter than wild-type controls (J:124813)

skeleton
• either the middle or proximal phalanx is usually lost
• homozygotes display a modest size reduction in the long bones of the extremities relative to wild-type controls
• mutant phalanges excluding the terminal one appear underdeveloped

reproductive system
• homozygotes produce significantly fewer live born pups per litter relative to wild-type controls (5.3 +/- 1.7 vs 6.4 +/- 2.2, respectively)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory