Phenotypes associated with this allele

• Allele Symbol: cby
• Allele Name: chubby
• Allele ID: MGI:1856815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	cby/cby	Peru-Coppock stock	MGI:2660659

Genotype
MGI:2660659

hm1

• Allelic Composition: cby/cby
• Genetic Background: Peru-Coppock stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

decreased cranium height ( J:8685 )

short snout ( J:8685 )

shortened head ( J:8685 )

• obvious by 15 days of age

growth/size/body

short snout ( J:8685 )

shortened head ( J:8685 )

• obvious by 15 days of age

disproportionate dwarf ( J:8685 )

• mild, disproportionate dwarfism is seen by the onset of the third week following birth

limbs/digits/tail

brachydactyly ( J:8685 )

short femur ( J:8685 )

short tibia ( J:8685 )

decreased distal limb length ( J:8685 )

• distal parts of the extremities are more affected than the proximal parts

skeleton

decreased cranium height ( J:8685 )

abnormal long bone epiphysis morphology ( J:8685 )

• the epiphyseal bone displays a gracile spongiosa and a thin cortex

abnormal long bone metaphysis morphology ( J:8685 )

• the primary metaphyseal spongy bone is poorly developed and extremely fragile

decreased length of long bones ( J:8685 )

short femur ( J:8685 )

short tibia ( J:8685 )

abnormal trabecular bone morphology ( J:8685 )

• primary metaphyseal spongy bone is poorly developed and extremely fragile while the epiphyseal bone shows a gracile spongiosa

• bone trabeculae is considerably coarser and more irregular in the metaphysis

abnormal cartilage morphology ( J:8685 )

• irregular mineralization of cartilage, extensive cell death and accumulations of matrix vesicles in the extracellular matrix

abnormal long bone epiphyseal plate morphology ( J:8685 )

• increase in height of the epiphyseal growth cartilage

• the extracellular matrix of the resting epiphyseal zone contains enormous amounts of membranous material with varying shape and electron density and matrix vesicles

abnormal long bone epiphyseal plate proliferative zone ( J:8685 )

• proliferative zone contains disintegrating cells and the normal columnar organization is severely disturbed

abnormal long bone hypertrophic chondrocyte zone ( J:8685 )

• areas with thin-walled blood vessels are sometimes observed in the hypertrophic zone

• extracellular matrix of the hypertrophic zone contains very high amounts of membranous material and matrix vesicles

abnormal cartilage development ( J:8685 )

• chondroitin sulfate chains are considerably longer than in normal mice

abnormal endochondral bone ossification ( J:8685 )

• mineralization of cartilage in the tibia is irregular, with some mutants showing strands of residual unmineralized cartilage that extends far down into the metaphysis

reproductive system

decreased litter size ( J:8685 )

• litter size from most of cby by cby matings are small, probably due to the tendency, in successive breeding by such matings, for the cby females to become smaller in overall size