Analysis Tools
behavior/neurological
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• a test in which an auditory cue was coupled with a foot shock failed to elicit a startle response to the auditory cue after training in mutant mice
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• the amplitude of the acoustic startle response was larger in mutant mice
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limb grasping
(
J:38887
)
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• mice often hold their tails off the surface when walking and sometimes arch the tail over their backs
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• females take poor care of offspring
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growth/size/body
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• mice weigh approximately 25% less than littermate controls before weaning, mice weigh approximately 50% less than littermate controls throughout adulthood
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hearing/vestibular/ear
| N |
• mice exhibit normal auditory brainstem (ABR) responses indicating that mutant mice can hear normally
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• elevated threshold
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hematopoietic system
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• slightly higher than controls, but within values expected for the background strain
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reproductive system
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• males rarely breed
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nervous system
| N |
• EEG patterns were similar to controls
• normal histopathology of the cerebrum, thalamus, brainstem, spinal cord was noted
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• most lobules are shortened in length
(J:70222)
• lobulation began between P2 and P4 instead of P0 as in controls
(J:74540)
• lobulation continued to be delayed past the first postnatal week
(J:74540)
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• folia is reduced to 7 as contrasted with the wild-type folia count of 10; foliation pattern is also perturbed
(J:38887)
• absence of intraculmenate fissure that divides the culmen into two lobules, 4 and 5
(J:38887)
• absence of the declivis 6a and 6b
(J:38887)
• absence of fissura seconda that separates the pyramis 8 from the uvula 9
(J:38887)
• absence of uvula 9b and 9c
(J:38887)
• the precentral fissure between lobules II and III is rudimentary
(J:70222)
• at P0 and P2, cerebella lacked fissures unlike controls
(J:74540)
• the prepyramidal fissure appeared at P8
(J:74540)
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• in the pyramidal cell layer, pyramidal cells were less densely packed compared to wild-type mice, and occasionally appears as isolated cells
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• pyramidal cells of the CA1, CA2, and CA3 region were scattered into the external and deep plexiform layers of the hippocampus
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• Purkinje cells were observed in the granule cell layer and in the white matter
(J:38887)
• a failure of Purkinje cell migration during development results in widespread ectopia in the adult
(J:70222)
• the cells are not arranged in the normal monolayer in the cerebellum and appear in the deep core of the cerebellum, the granular layer, and the intralobular white matter
(J:70222)
• total numbers of Purkinje cells appeared similar in mutant mice and controls
(J:70222)
• ectopic Purkinje cells were those primarily not expressing zebrin II
(J:70222)
• at P0, Purkinje cells are scattered throughout the white matter
(J:74540)
• at P4, some Purkinje cells had aligned in a single layer, but many remained at ectopic sites
(J:74540)
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• reduced number of granule cells were observed at 5 months of age
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• mineral deposits seen in the ventral vermis of the midline
(J:38887)
• vermis is reduced in rostro-caudal length by more than one third
(J:70222)
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• reduced in overall size compared to controls
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• midsagittal area of the mutant cerebellum is ~60% that of control mice
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• a weaker PPI was seen compared to controls
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