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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		CoblC101
cordon-bleu 101
MGI:1856827
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		CoblC101/CoblC101 involves: 129/Sv * 129S2/SvPas MGI:2664303
cx2
 		CoblC101/CoblC101
Vangl2Lp/Vangl2Lp 		involves: 129S2/SvPas * LPT/LeJ MGI:2677879
cx3
 		CoblC101/CoblC101
Vangl2Lp/Vangl2+ 		involves: 129S2/SvPas * LPT/LeJ MGI:2677880


Genotype
MGI:2664303
hm1
Allelic
Composition		 CoblC101/CoblC101
Genetic
Background		 involves: 129/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CoblC101 mutation (0 available); any Cobl mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:28764 )
• mice are healthy and fertile with no observable phenotype




Genotype
MGI:2677879
cx2
Allelic
Composition		 CoblC101/CoblC101
Vangl2Lp/Vangl2Lp
Genetic
Background		 involves: 129S2/SvPas * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CoblC101 mutation (0 available); any Cobl mutation (78 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:85744 )
• in double homozygotes there is a rostral extension of the neural tube defect such that embryos display an open neural tube from the midbrain to the tail in 36% of the mice




Genotype
MGI:2677880
cx3
Allelic
Composition		 CoblC101/CoblC101
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129S2/SvPas * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CoblC101 mutation (0 available); any Cobl mutation (78 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
exencephaly ( J:85744 )
• open neural tubes in the midbrain region
• observable by E9.5 and occurring with 20% penetrance, this phenotype was not observed in lone C101 homozygotes or lone Lp heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory