Phenotypes associated with this allele

• Allele Symbol: cod
• Allele Name: cerebellar outflow degeneration
• Allele ID: MGI:1856828
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	cod/cod	involves: BALB/cGr	MGI:3789582
hm2	cod/cod	Not Specified	MGI:2664304

Genotype
MGI:3789582

hm1

• Allelic Composition: cod/cod
• Genetic Background: involves: BALB/cGr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:13855 )

• Background Sensitivity: abnormalities become consistent on the BALB/cGr inbred strain

lethargy ( J:13855 )

• Background Sensitivity: noted at 45 days of age and present through lifespan

ataxia ( J:13855 )

• Background Sensitivity: noted at 45 days of age and present through lifespan

impaired balance ( J:13855 )

• Background Sensitivity: noted at 12 days of age when mouse is moved; observed during unprovoked activity by 15 days of age

impaired swimming ( J:13855 )

• Background Sensitivity: noted at 45 days of age and present through lifespan

abnormal limb posture ( J:13855 )

• Background Sensitivity: noted at 45 days of age and present through lifespan

head bobbing ( J:13855 )

• Background Sensitivity: noted at 45 days of age and present through lifespan

nervous system

abnormal nervous system morphology ( J:13855 )

• Background Sensitivity: abnormalities become consistent on the BALB/cGr inbred strain

abnormal brainstem morphology ( J:13855 )

• Background Sensitivity: pathological changes at 11 days of age

neurodegeneration ( J:13855 )

• Background Sensitivity: at 11 days of age, chromatolysis in vestibular and red nuclei are seen with degenerative changes in intermediate and distal aspects of axons

• Background Sensitivity: between 25 and 60 days of age, additional nuclear groups and axonal systems are affected

reproductive system

female infertility ( J:13855 )

♀

male infertility ( J:13855 )

♂

Genotype
MGI:2664304

hm2

• Allelic Composition: cod/cod
• Genetic Background: Not Specified

mortality/aging

lethality at weaning, incomplete penetrance ( J:13460 )

• some homozygotes die at weaning

preweaning lethality, incomplete penetrance ( J:13460 )

• some homozygotes die before weaning

growth/size/body

decreased body size ( J:13460 )

• homozygotes display a reduced body size

behavior/neurological

impaired balance ( J:13460 )

• homozygotes appear to be unsteady on their feet during the third week of life

impaired limb coordination ( J:13460 )

• surviving homozygotes display an awkard use of the hindlimbs and trunk while swimming, but are otherwise overtly normal

impaired swimming ( J:13460 )

• surviving homozygotes display an awkard use of the hindlimbs and trunk while swimming, but are otherwise overtly normal

weakness ( J:13460 )

• homozygotes appear weak during the third week of life

abnormal gait ( J:13460 )

• homozygotes are clumsy in movement during the third week of life

bradykinesia ( J:13460 )

• homozygotes are slow in movement during the third week of life

nervous system

astrocytosis ( J:13460 )

• at 3-4 months of age, homozygotes display a striking astrogliosis in the superior cerebellar peduncle as well as in the deep cerebellar nuclei, in the red nuclei of the midbrain, and in the ventral thalamus

• astrogliosis is only moderately advanced at 6 weeks of age

neuron degeneration ( J:13460 )

• at 3-4 months of age, homozygotes exhibit neuron degeneration in the deep cerebellar nuclei (dentate, interpositus, and fastigial nuclei), in the red nuclei of the midbrain, and in the ventral thalamus

• neuron loss is only moderately advanced at 6 weeks of age

muscle

decreased skeletal muscle fiber diameter ( J:13460 )

• the diameter of skeletal muscle fibers is slightly smaller than normal

• however, no major pathological changes are observed