Phenotypes associated with this allele

• Allele Symbol: Tg^cog
• Allele Name: congenital goiter
• Allele ID: MGI:1856829
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tg^cog/Tg^cog	AKR/J-Tg^cog	MGI:3032546
hm2	Tg^cog/Tg^cog	involves: AKR/J * C57BL/6By	MGI:3032571

Genotype
MGI:3032546

hm1

• Allelic Composition: Tg^cog/Tg^cog
• Genetic Background: AKR/J-Tg^cog

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:13923 )

• obliteration of most follicular lumens

• small numbers of lymphocytes in degenerating follicles

abnormal thyroid follicular cell morphology ( J:13923 )

• hypertrophy and hyperplasia of thyrofollicular cells

enlarged thyroid gland ( J:13923 )

• reduced when diet supplemented with desiccated thyroid powder

growth/size/body

disproportionate dwarf ( J:13923 )

• evident at day 15 postnatal

• repaired when diet supplemented with desiccated thyroid powder

increased growth rate ( J:13923 )

• evident between 4 and 7 weeks of age

homeostasis/metabolism

decreased circulating thyroxine level ( J:13923 )

• serum thyroxine is significantly reduced

Genotype
MGI:3032571

hm2

• Allelic Composition: Tg^cog/Tg^cog
• Genetic Background: involves: AKR/J * C57BL/6By

endocrine/exocrine glands

enlarged thyroid gland ( J:8567 )

• hypertrophy of thyrofollicular cells

growth/size/body

decreased body weight ( J:3079 , J:8567 )

• evident at day 15 postnatal (J:3079)

• evident by 15 days postnatal (J:8567)

• repaired when diet at weaning was supplemented with desiccated thyroid powder (J:8567)

hematopoietic system

anemia ( J:8567 )

decreased hematocrit ( J:8567 )

homeostasis/metabolism

decreased circulating thyroxine level ( J:8567 )

decreased circulating triiodothyronine level ( J:8567 )

increased circulating thyroid-stimulating hormone level ( J:8567 )

nervous system

decreased brain weight ( J:3079 )

• cerebrum and cerebellum weighed significantly less than littermate controls

• brain stem weight equivalent to littermate controls

abnormal myelination ( J:3079 )

• hypomyelination, restricted to cerebrum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital hypothyroidism		DOID:0050328	OMIM:PS275200	J:8567