Phenotypes associated with this allele

• Allele Symbol: crn
• Allele Name: cranioschisis
• Allele ID: MGI:1856835
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	crn/crn	Not Specified	MGI:4367738

Genotype
MGI:4367738

hm1

• Allelic Composition: crn/crn
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:12965 )

• newborns do not nurse and die or are killed by mother

nervous system

abnormal neural tube closure ( J:7673 )

• in region of primary brain vesicles, and cervical and cephalic flexures

• due to neural tube supporting mesenchyme defect

abnormal brain development ( J:12965 )

• disorganized neural overgrowth accompanies cases of extreme anencephaly

anencephaly ( J:12965 )

• degree varies from 1mm diameter skin and frontal cranium defect to absence of calvarium above level of orbit

exencephaly ( J:7673 )

• affected fetuses with this condition suffer petechiae and abrasions to the brain; at birth neural tissue is necrotic or becomes damaged

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:12965 )

• reduced numbers of calcified vertebrae

craniofacial

abnormal neurocranium morphology ( J:12965 )

abnormal frontal bone morphology ( J:12965 )

• minimal defect is a 1mm diameter skin and frontal cranium abnormality

absent neurocranium ( J:12965 )

cleft palate ( J:12965 )

skeleton

abnormal neurocranium morphology ( J:12965 )

abnormal frontal bone morphology ( J:12965 )

• minimal defect is a 1mm diameter skin and frontal cranium abnormality

absent neurocranium ( J:12965 )

abnormal caudal vertebrae morphology ( J:12965 )

• reduced numbers of calcified vertebrae

digestive/alimentary system

cleft palate ( J:12965 )

embryo

abnormal mesenchyme morphology ( J:7673 )

• neural tube supporting mesenchyme loses normal stellate cellular inerconnections for not more than 24 hours but long enough to disrupt important cell/matrix interactions

abnormal neural tube closure ( J:7673 )

• in region of primary brain vesicles, and cervical and cephalic flexures

• due to neural tube supporting mesenchyme defect

growth/size/body

cleft palate ( J:12965 )