All Phenotypes Grhl3<ct> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grhl3^ct
curly tail
MGI:1856837

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grhl3^ct/Grhl3^ct	GFF-Grhl3^ct	MGI:3794043
hm2	Grhl3^ct/Grhl3^ct	involves: CBA/Gr * GFF	MGI:3794033
hm3	Grhl3^ct/Grhl3^ct	involves: GFF	MGI:3794050
hm4	Grhl3^ct/Grhl3^ct	STOCK Grhl3^ct/J	MGI:3794106
ht5	Grhl3^ct/Grhl3⁺	involves: C57BL/6 * GFF	MGI:3794062
ht6	Grhl3^ct/Grhl3^tm1Jane	involves: 129S1/Sv * C57BL/6 * STOCK ct/J	MGI:2684380
ht7	Grhl3^ct/Grhl3^ct-J	Not Specified	MGI:2687310
cx8	Grhl3^ct/? Vangl2^Lp/Vangl2⁺	involves: A * GFF	MGI:3794074
cx9	Axd/Axd⁺ Grhl3^ct/Grhl3⁺	involves: BALB/c * C3H/HeN * C57BL/6 * GFF	MGI:4948895
cx10	Grhl3^ct/Grhl3^ct Tg(Grhl3)1Ndeg/0	involves: GFF	MGI:3794068

Allelic Composition	Grhl3^ct/Grhl3^ct
Genetic Background	GFF-Grhl3^ct

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:6864 )

nervous system

abnormal neural tube closure ( J:1549 , J:6246 )

• inositol deficiency in the culture medium increases the frequency of neural tube defects (J:1549)

• administration of vitamin A to mothers on day 8 of pregnancy increases the frequency of neural tube defects in homozygous ct offspring, but vitamin A administration on day 9 causes a marked decrease (J:6246)

spina bifida ( J:6864 )

exencephaly ( J:6245 , J:6864 )

• there is a great preponderance of females among exencephalic embryos (J:6245)

• rare (J:6864)

growth/size/body

fetal growth retardation ( J:6864 )

embryo

abnormal neural tube closure ( J:1549 , J:6246 )

• inositol deficiency in the culture medium increases the frequency of neural tube defects (J:1549)

spina bifida ( J:6864 )

Allelic Composition	Grhl3^ct/Grhl3^ct
Genetic Background	involves: CBA/Gr * GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:264 )

• mice exhibit varying decrees of tail curl

nervous system

delayed neural tube closure ( J:79 )

spina bifida ( J:264 )

• in some mice

anencephaly ( J:264 )

• rarely

embryo

abnormal dorsal-ventral axis patterning ( J:79 )

• embryos display significantly greater ventral curvature of the body axis in the neuropore region than do normal embryos

delayed neural tube closure ( J:79 )

spina bifida ( J:264 )

• in some mice

Allelic Composition	Grhl3^ct/Grhl3^ct
Genetic Background	involves: GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:14716 )

nervous system

abnormal neural tube closure ( J:14716 )

• neural tube defects are more severe than in ct homozygotes

spina bifida ( J:14716 )

embryo

abnormal neural tube closure ( J:14716 )

• neural tube defects are more severe than in ct homozygotes

spina bifida ( J:14716 )

Allelic Composition	Grhl3^ct/Grhl3^ct
Genetic Background	STOCK Grhl3^ct/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida cystica ( J:86772 )

• 12% of mice exhibit spina bifida aperta that is reduced by 53% following treatment with inositol

exencephaly ( J:86772 )

• in 3% of mice

limbs/digits/tail

curly tail ( J:86772 )

• in 50% of mice

embryo

spina bifida cystica ( J:86772 )

• 12% of mice exhibit spina bifida aperta that is reduced by 53% following treatment with inositol

growth/size/body

spina bifida cystica ( J:86772 )

• 12% of mice exhibit spina bifida aperta that is reduced by 53% following treatment with inositol

Allelic Composition	Grhl3^ct/Grhl3⁺
Genetic Background	involves: C57BL/6 * GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:24376 )

• 8 of 36 mice are affected

Allelic Composition	Grhl3^ct/Grhl3^tm1Jane
Genetic Background	involves: 129S1/Sv * C57BL/6 * STOCK ct/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)
Grhl3^tm1Jane mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:86772 )

• the incidence of spina bifida in these embryos was higher than reported for ct homozygotes (31% vs 12%, respectively)

• the extent of the spina bifida more closely resembled ct (lumbosacral spina bifida) than the null allele (thorocolumbosacral)

• 14% of the mice had tail flexion defects only

• 5% of mice with this genotype were normal

embryo

spina bifida ( J:86772 )

• the incidence of spina bifida in these embryos was higher than reported for ct homozygotes (31% vs 12%, respectively)

• the extent of the spina bifida more closely resembled ct (lumbosacral spina bifida) than the null allele (thorocolumbosacral)

• 14% of the mice had tail flexion defects only

• 5% of mice with this genotype were normal

Allelic Composition	Grhl3^ct/Grhl3^ct-J
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)
Grhl3^ct-J mutation (0 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:87487 )

• crosses between ct^J homozygotes and mice of the homozygous STOCK ct/J line, within which 30-50% of mice are affected, yielded only ~7.4% affected offspring; the reduced penetrance of the phenotype in the presumed complex heterozygote may be due either to the combination of the two ct alleles or to a "hybrid vigor" effect of combining the by-now inbred genetic backgrounds

nervous system

open neural tube ( J:87487 )

embryo

open neural tube ( J:87487 )

Allelic Composition	Grhl3^ct/? Vangl2^Lp/Vangl2⁺
Genetic Background	involves: A * GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

meningomyelocele ( J:125330 )

• mice exhibit meningomyelocele

abnormal astrocyte morphology ( J:125330 )

• at E16.5 and E18.5 mice with meningomyelocele display increased astrocyte staining compared to in wild-type mice

abnormal spinal cord morphology ( J:125330 )

• in mice with meningomyelocele, the dorsal region of the neural tube lays laterally to the ventral horn and the dorsal white matter is moved into a ventrolateral position unlike in wild-type mice

• at E16.5, the number of neuronal cells in the meningomyelocele placode is decreased compared to in wild-type mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:125330 )

• mice exhibit meningomyelocele with hypotonic hindlimbs with spontaneous and extensive movement of the hip and knee joints but only slight movement at the ankle joints

• mice do not display coordination between fore- and hindlimbs

• mice occasionally exhibit plantar steps that demonstrate the ability to support their body weight

growth/size/body

decreased fetal weight ( J:125330 )

• mice with meningomyelocele exhibit reduced fetal weight

skeleton

meningomyelocele ( J:125330 )

• mice exhibit meningomyelocele

embryo

meningomyelocele ( J:125330 )

• mice exhibit meningomyelocele

Allelic Composition	Axd/Axd⁺ Grhl3^ct/Grhl3⁺
Genetic Background	involves: BALB/c * C3H/HeN * C57BL/6 * GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axd mutation (1 available); any Axd mutation (1 available)
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:170759 )

• the frequency of curled tails is increased 2.5-fold compared to in Grhl3^ct heterozygotes

Allelic Composition	Grhl3^ct/Grhl3^ct Tg(Grhl3)1Ndeg/0
Genetic Background	involves: GFF

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^ct mutation (2 available); any Grhl3 mutation (53 available)
Tg(Grhl3)1Ndeg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:129979 )

N	• unlike ct homozygotes, mice exhibit normal neural tube closure

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