Phenotypes associated with this allele

• Allele Symbol: Zdhhc21^dep
• Allele Name: depilated
• Allele ID: MGI:1856841
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zdhhc21^dep/Zdhhc21^dep	involves: C3HeB/FeJ * C57BL/6J * STOCK T tf/+ tf	MGI:3833848
hm2	Zdhhc21^dep/Zdhhc21^dep	involves: C57BL/6J * STOCK T tf/+ tf	MGI:4462157

Genotype
MGI:3833848

hm1

• Allelic Composition: Zdhhc21^dep/Zdhhc21^dep
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J * STOCK T tf/+ tf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal hair shaft melanin granule morphology ( J:5722 , J:20220 )

• clumps of pigment appear to be the remains of degenerating follicles (J:5722)

• excessive accumulation and clumping of pigment in the hair (J:20220)

integument

abnormal coat appearance ( J:20220 )

• identifiable at about 1 week of age when first coat appears

abnormal hair shaft melanin granule morphology ( J:5722 , J:20220 )

• clumps of pigment appear to be the remains of degenerating follicles (J:5722)

• excessive accumulation and clumping of pigment in the hair (J:20220)

abnormal hair growth ( J:5722 )

premature hair loss ( J:20220 )

• some mice are nearly hairless at 3 weeks of age; others may have a nearly normal coat

short hair ( J:5722 )

sparse hair ( J:20220 )

matted coat ( J:20220 )

greasy coat ( J:20220 )

abnormal hair medullary septa cells ( J:5722 )

• 20% of coat hairs show an irregular arrangement of septa or complete interruption of septa

abnormal hair follicle morphology ( J:5722 )

abnormal hair follicle orientation ( J:5722 )

abnormal hair cycle ( J:20220 )

abnormal epidermal layer morphology ( J:5722 )

• dermal-epidermal recombination grafts of embryonic skin shows this allele acts in the epidermis

Genotype
MGI:4462157

hm2

• Allelic Composition: Zdhhc21^dep/Zdhhc21^dep
• Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

endocrine/exocrine glands

enlarged sebaceous gland ( J:161749 )

• enlarged sebaceous glands with an excess of sebum

sebaceous gland hyperplasia ( J:161749 )

• mild sebaceous gland hyperplasia at P5

abnormal sebaceous gland physiology ( J:161749 )

• increase in the percentage of BrdU positive, proliferating cells that are observed in sebaceous glands

increased sebum secretion ( J:161749 )

• excess of sebum

integument

enlarged sebaceous gland ( J:161749 )

• enlarged sebaceous glands with an excess of sebum

sebaceous gland hyperplasia ( J:161749 )

• mild sebaceous gland hyperplasia at P5

abnormal sebaceous gland physiology ( J:161749 )

• increase in the percentage of BrdU positive, proliferating cells that are observed in sebaceous glands

increased sebum secretion ( J:161749 )

• excess of sebum

abnormal coat appearance ( J:161749 )

greasy coat ( J:161749 )

underdeveloped hair follicles ( J:161749 )

• second hair cycle around P28, the follicles are growth retarded and immature compared to wild-type

dilated hair follicle infundibulum ( J:161749 )

• in telogen defects in the permanent portions of the skin are apparent, include a dilated infundibulum

abnormal hair follicle physiology ( J:161749 )

• decrease of proliferating cells in hair follicles during anagen

abnormal epidermal layer morphology ( J:161749 )

• slight thickening of the interfollicular epidermis develop at P5

epidermal cyst ( J:161749 )

• small epidermal cysts containing keratinized material are observed in the upper portion of the dermis

thick epidermis ( J:161749 )

abnormal skin physiology ( J:161749 )

• increase in the fraction of BrdU positive, proliferating interfollicular epidermis cells

• delayed differentiation of the expanded basal progenitor compartment

craniofacial

craniofacial phenotype ( J:177282 )

N • mutants do not exhibit sutural abnormalities

growth/size/body

epidermal cyst ( J:161749 )

• small epidermal cysts containing keratinized material are observed in the upper portion of the dermis