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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prop1df
Ames dwarf
MGI:1856842
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prop1df/Prop1df DF MGI:3802836
hm2
 		Prop1df/Prop1df involves: C57BL/6J MGI:3521856
hm3
 		Prop1df/Prop1df Not Specified MGI:3849016
hm4
 		Prop1df/Prop1df STOCK Prop1df MGI:3042606
cx5
 		Lhx4tm1Ssp/Lhx4tm1Ssp
Prop1df/Prop1df 		involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock MGI:3582582


Genotype
MGI:3802836
hm1
Allelic
Composition		 Prop1df/Prop1df
Genetic
Background		 DF
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prop1df mutation (2 available); any Prop1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pituitary gland morphology ( J:108961 )
• dysmorphic pituitary at birth when the pituitary is still normal size, and at 11 days of age when the pituitary is hypomorphic
pituitary gland hypoplasia ( J:108961 )
• evident by 11 days of age
abnormal granulosa cell morphology ( J:307483 )
• fewer granuolsa cells in primordial and primary ovarian follicles

reproductive system
abnormal granulosa cell morphology ( J:307483 )
• fewer granuolsa cells in primordial and primary ovarian follicles

nervous system
abnormal pituitary gland morphology ( J:108961 )
• dysmorphic pituitary at birth when the pituitary is still normal size, and at 11 days of age when the pituitary is hypomorphic
pituitary gland hypoplasia ( J:108961 )
• evident by 11 days of age

growth/size/body
decreased body size ( J:108961 )
• although homozygotes are the same size as control littermates at birth, they begin to be smaller at 2 weeks of age, are noticably smaller by 3 weeks of age, and are only one third to one quarter the size of normal littermates as adults




Genotype
MGI:3521856
hm2
Allelic
Composition		 Prop1df/Prop1df
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prop1df mutation (2 available); any Prop1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:94409 )
• a fraction of pups with a higher contribution of the C57BL/6J background display lethargy and die precipitously between weaning and adulthood

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:94409 )
N
• mutants crossed onto the C57BL/6J background have normal levels of gonadotropes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hypopituitarism DOID:9406 OMIM:221750
OMIM:262600
OMIM:262700
OMIM:613038
OMIM:613986
 J:94409




Genotype
MGI:3849016
hm3
Allelic
Composition		 Prop1df/Prop1df
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prop1df mutation (2 available); any Prop1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:84401 )
• homozygotes have altered activity in several liver enzymes involved in methionine cycling and transsulfuration, including a 205% increase in methionine adenosyltransferase activity, a 91% increase in glycine-N-transferase activity, a 50% increase in cystathionine synthase activity, and an 83% increase in cystationase activity




Genotype
MGI:3042606
hm4
Allelic
Composition		 Prop1df/Prop1df
Genetic
Background		 STOCK Prop1df
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prop1df mutation (2 available); any Prop1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:12169 )
N
• testes nearly normal
absent somatotrophs ( J:7211 )
• pituitary gland lacked identifiable somatotropes
decreased thyrotroph cell number ( J:12169 )
• reduced numbers of thyrotropic hormone producing cells
small adenohypophysis ( J:12169 )
• anterior pituitary reduced in size
small thyroid gland ( J:12169 )
• follicles were small and some tissue was not organized into follicles
absent tertiary ovarian follicles ( J:12169 )
• large follicles absent

growth/size/body
proportional dwarf ( J:36967 )
• daily i.p. injections of bovine growth hormone for ~ 6 weeks produced animals of nearly normal size

homeostasis/metabolism
decreased follicle stimulating hormone level ( J:5900 )
• males, in the pituitary
decreased circulating follicle stimulating hormone level ( J:5900 )
• males
• treatment with ovine prolactin or prolactin producing grafts, resulted in increased FSH levels
decreased luteinizing hormone level ( J:5900 )
• males, in the pituitary

reproductive system
absent tertiary ovarian follicles ( J:12169 )
• large follicles absent
female infertility ( J:36967 )
• still infertile after treatment with bovine growth hormone
male infertility ( J:36967 )
• became fertile after treatment with bovine growth hormone

nervous system
absent somatotrophs ( J:7211 )
• pituitary gland lacked identifiable somatotropes
decreased thyrotroph cell number ( J:12169 )
• reduced numbers of thyrotropic hormone producing cells
small adenohypophysis ( J:12169 )
• anterior pituitary reduced in size

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hypopituitarism DOID:9406 OMIM:221750
OMIM:262600
OMIM:262700
OMIM:613038
OMIM:613986
 J:5900 , J:6340 , J:7211 , J:12169 , J:36967




Genotype
MGI:3582582
cx5
Allelic
Composition		 Lhx4tm1Ssp/Lhx4tm1Ssp
Prop1df/Prop1df
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CF-1 * Goodale large mice * pink-eyed stock
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx4tm1Ssp mutation (1 available); any Lhx4 mutation (25 available)
Prop1df mutation (2 available); any Prop1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal Rathke's pouch apoptosis ( J:79850 )
• in pituitary primordia
abnormal Rathke's pouch development ( J:79850 )
• Rathke's pouch is smaller than normal at E12.5
• sometimes a smaller ventral pouch forms
absent gonadotrophs ( J:79850 )
• gonadotrope cells absent
absent adenohypophysis ( J:79850 )
• anterior lobes of pituitary never form

homeostasis/metabolism
decreased pituitary hormone level ( J:79850 )
• pro-opiomelanocortin in the pituitary detectable at birth but only in scattered intermediate lobe cells
decreased growth hormone level ( J:79850 )
• lacking in pituitary

nervous system
abnormal Rathke's pouch apoptosis ( J:79850 )
• in pituitary primordia
abnormal Rathke's pouch development ( J:79850 )
• Rathke's pouch is smaller than normal at E12.5
• sometimes a smaller ventral pouch forms
absent gonadotrophs ( J:79850 )
• gonadotrope cells absent
absent adenohypophysis ( J:79850 )
• anterior lobes of pituitary never form




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory