Phenotypes associated with this allele

• Allele Symbol: dm
• Allele Name: diminutive
• Allele ID: MGI:1856844
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	dm/dm	involves: 129 * BALB/cJ * C57L/J	MGI:3789008

Genotype
MGI:3789008

hm1

• Allelic Composition: dm/dm
• Genetic Background: involves: 129 * BALB/cJ * C57L/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:2479 )

• Background Sensitivity: zero to 25 per cent survive, depending on genetic background

neonatal lethality, incomplete penetrance ( J:2479 )

• Background Sensitivity: variable length of survival, depending on genetic background

growth/size/body

decreased body size ( J:2479 )

• across their life span, mutant mice are much smaller than their normal siblings

decreased body weight ( J:2479 )

• at birth mutants weigh 57% of normal littermate weight

• at 60 days of age, mutant mice weigh 72% of normal littermate weight

hematopoietic system

decreased common myeloid progenitor cell number ( J:5439 )

• bone marrow contains only half the expected number of colony forming units

macrocytic anemia ( J:2479 )

• mice are affected as newborns and recognized by extreme pallor

• less severe in older mice

limbs/digits/tail

abnormal tail morphology ( J:2479 )

short tail ( J:2479 )

kinked tail ( J:2479 )

skeleton

abnormal axial skeleton morphology ( J:2479 )

increased rib number ( J:2479 )

• mutant mice tend to have an additional rib at both the cervical and lumbar ends of the thorax

rib fusion ( J:2479 )

• ribs may be fused

abnormal vertebrae morphology ( J:2479 )

abnormal presacral vertebrae morphology ( J:2479 )

increased presacral vertebrae number ( J:2479 )

• one additional presacral vertebra