All Phenotypes Mreg<dsu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mreg^dsu
dilute suppressor
MGI:1856847

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mreg^dsu/Mreg^dsu Rab27a^ash/Rab27a^ash	involves: C3H/HeSn	MGI:3768125
cx2	Hps3^coa/Hps3^coa Myo5a^d/Myo5a^d Mreg^dsu/Mreg^dsu	involves: C57BL/10J	MGI:3587103
cx3	Mreg^dsu/Mreg^dsu Myo5a^d-l20J/Myo5a^d-l20J	involves: C57BL/6J	MGI:3768126
cx4	a/a Mreg^dsu/Mreg^dsu Hps6^ru/Hps6^ru	involves: C57BL/6J	MGI:5466757
cx5	Mlph^ln/Mlph^ln Mreg^dsu/Mreg^dsu	involves: C57BR	MGI:3768124
cx6	Mreg^dsu/Mreg^dsu Myo5a^d/Myo5a^d	involves: DBA/2J	MGI:3768122
cx7	Mreg^dsu/Mreg^dsu Myo5a^d/Myo5a^d	STOCK a Myo5a^d Hephl1^cw	MGI:3768123

Allelic Composition	Mreg^dsu/Mreg^dsu Rab27a^ash/Rab27a^ash
Genetic Background	involves: C3H/HeSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)
Rab27a^ash mutation (3 available); any Rab27a mutation (146 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:9309 )

• diluted coat color caused by the Rab27a^ash allele is partially suppressed

integument

diluted coat color ( J:9309 )

• diluted coat color caused by the Rab27a^ash allele is partially suppressed

Allelic Composition	Hps3^coa/Hps3^coa Myo5a^d/Myo5a^d Mreg^dsu/Mreg^dsu
Genetic Background	involves: C57BL/10J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hps3^coa mutation (1 available); any Hps3 mutation (54 available)
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)
Myo5a^d mutation (105 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye pigmentation ( J:29467 )

• lack eye pigment

pigmentation

diluted coat color ( J:29467 )

• paler coat color in both juveniles and adults

• ear pinna lack pigment at 3-4 days of age

• extremities light in color

abnormal eye pigmentation ( J:29467 )

• lack eye pigment

integument

diluted coat color ( J:29467 )

• paler coat color in both juveniles and adults

• ear pinna lack pigment at 3-4 days of age

• extremities light in color

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Hermansky-Pudlak syndrome 3		DOID:0060541	OMIM:614072	J:29467

Allelic Composition	Mreg^dsu/Mreg^dsu Myo5a^d-l20J/Myo5a^d-l20J
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)
Myo5a^d-l20J mutation (0 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:20299 )

N	• mice display a normal coat color unlike the diluted coat color normally observed in Myo5a^d-120J mice

behavior/neurological

opisthotonus ( J:20299 )

• neurological defects are not rescued

muscle

opisthotonus ( J:20299 )

• neurological defects are not rescued

Allelic Composition	a/a Mreg^dsu/Mreg^dsu Hps6^ru/Hps6^ru
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Hps6^ru mutation (3 available); any Hps6 mutation (28 available)
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

phenotypic reversion ( J:29467 )

• products of this genotype normalize eye color from ruby to wild-type black

integument

diluted coat color ( J:29467 )

• coat color dilution is not affected by the dilute repressor mutation, Mreg^dsu

• the wild-type nonagouti black coat is diluted to a dull reddish brown

pigmentation

diluted coat color ( J:29467 )

• coat color dilution is not affected by the dilute repressor mutation, Mreg^dsu

• the wild-type nonagouti black coat is diluted to a dull reddish brown

Allelic Composition	Mlph^ln/Mlph^ln Mreg^dsu/Mreg^dsu
Genetic Background	involves: C57BR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:9309 )

• diluted coat color caused by the Mlph^ln allele is partially suppressed

integument

diluted coat color ( J:9309 )

• diluted coat color caused by the Mlph^ln allele is partially suppressed

Allelic Composition	Mreg^dsu/Mreg^dsu Myo5a^d/Myo5a^d
Genetic Background	involves: DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mreg^dsu mutation (1 available); any Mreg mutation (103 available)
Myo5a^d mutation (105 available); any Myo5a mutation (265 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:7171 )

N	• mice display none of the neurological defects observed in Myo5a^d mice

pigmentation

pigmentation phenotype ( J:7171 )

N	• mice display a normal coat color unlike the diluted coat color normally observed in Myo5a^d mice

abnormal melanocyte morphology ( J:7171 )

• the number of melanocytes is increased compared to in Myo5a^d mice but is still lower than in wild-type mice

Allelic Composition	Mreg^dsu/Mreg^dsu Myo5a^d/Myo5a^d
Genetic Background	STOCK a Myo5a^d Hephl1^cw

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:9309 )

N	• mice display a normal coat color unlike the diluted coat color normally observed in Myo5a^d mice

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