Phenotypes associated with this allele

• Allele Symbol: ec
• Allele Name: ectopic
• Allele ID: MGI:1856853
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	ec/ec	BALB/c-ec	MGI:4367749

Genotype
MGI:4367749

hm1

• Allelic Composition: ec/ec
• Genetic Background: BALB/c-ec

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:13098 )

• at 28-30 days of age a discrete three point star type lens suture is observed on the posterior lens pole; the suture becomes more pronounced and bilateral with age

• the lens becomes posterior to the torn edges of the capsule by 6 weeks of age

abnormal lens capsule morphology ( J:13098 )

• at 5 weeks of age the lens capsule opens at points over suture lines that appear on the lens

ruptured lens capsule ( J:13098 )

• at approximately 5 weeks of age the lens is displaced posteriorly through the ruptured capsule

• rupture is preceded by enlargement of the lens

lens vacuoles ( J:13098 )

• by 6 weeks of age, increasing numbers of vacuoles appear in the body of the lens

lens dislocation ( J:13098 , J:65330 )

• ectopia of only the lens nucleus occurs; the suspensory fibers of the lens and the lens itself are not disturbed (J:13098)

cataract ( J:13098 , J:65330 )

• posterior lens opacity develops around 5 weeks of age (J:13098)

• progression of opacity is correlated with an opening of the posterior lens suture and rupture of the posterior lens capsule (J:13098)

enlarged lens ( J:13098 )

• pressure created by lens growth causes the eye to appear enlarged

small lens ( J:13098 )

macrophthalmia ( J:13098 )

• at 5 weeks of age eyes appears noticeably larger but the eye size parameters normalize after 6 weeks of age

behavior/neurological

increased blinking frequency ( J:13098 )

• due to enlarged eye

• can be used to distinguish mutant mice from normal siblings