Phenotypes associated with this allele

• Allele Symbol: epi
• Allele Name: exocrine pancreatic insufficiency
• Allele ID: MGI:1856860
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	epi/?	involves: CBA/J	MGI:4358698

Genotype
MGI:4358698

ot1

• Allelic Composition: epi/?
• Genetic Background: involves: CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:5421 )

perinatal lethality, incomplete penetrance ( J:27487 )

• there is high mortality among affected mice

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:27487 )

• normal acinar tissue is partially or completely replaced by adipose tissue; islets of Langerhans are normal

pancreatic acinar hypoplasia ( J:5752 )

• acinar tissue is autodigested

exocrine pancreas hypoplasia ( J:5421 )

growth/size/body

decreased body size ( J:5421 , J:27487 )

• at 2-3 weeks of age affected mice are smaller compared with normal littermates (J:5421)

• pancreatin supplement somewhat normalized the smaller size of affected mice (J:27487)

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:27487 )

• normal acinar tissue is partially or completely replaced by adipose tissue; islets of Langerhans are normal

pancreatic acinar hypoplasia ( J:5752 )

• acinar tissue is autodigested

exocrine pancreas hypoplasia ( J:5421 )

abnormal feces composition ( J:5421 , J:27487 )

• feces of affected mice between 2 and 3 weeks of age are yellow and have an elevated fat content (J:5421)

• trypsin content is lower than in littermates (J:5421)

• pancreatin supplement somewhat normalized the composition (J:27487)

abnormal feces lipid level ( J:5421 )

• elevated fat content

steatorrhea ( J:5421 )

cellular

abnormal autophagy ( J:5752 )

• biochemical indicators show affected mice have abnormal pancreatic intracellular digestion

homeostasis/metabolism

abnormal autophagy ( J:5752 )

• biochemical indicators show affected mice have abnormal pancreatic intracellular digestion

abnormal feces lipid level ( J:5421 )

• elevated fat content

steatorrhea ( J:5421 )

decreased circulating glucose level ( J:5421 )

• affected mice had levels below normal limits; no glucosuria was detected

hematopoietic system

decreased hematocrit ( J:27487 )

• affected mice had a lower hematocrit compared with littermates

increased neutrophil cell number ( J:27487 )

• affected mice had a higher percentage of nuetrophils compared with littermates

decreased leukocyte cell number ( J:27487 )

• affected mice had a lower white blood cell count compared with littermates

decreased lymphocyte cell number ( J:27487 )

• affected mice had a lower percentage of lymphocytes compared with littermates

immune system

increased neutrophil cell number ( J:27487 )

• affected mice had a higher percentage of nuetrophils compared with littermates

decreased leukocyte cell number ( J:27487 )

• affected mice had a lower white blood cell count compared with littermates

decreased lymphocyte cell number ( J:27487 )

• affected mice had a lower percentage of lymphocytes compared with littermates