Phenotypes associated with this allele

• Allele Symbol: Rax^ey1
• Allele Name: eyeless 1
• Allele ID: MGI:1856862
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rax^ey1/Rax^ey1	involves: ZRDCT/Ch	MGI:3809662
hm2	Rax^ey1/Rax^ey1	ZRDCT/Ch-Rax^ey1	MGI:3809647
ht3	Rax^ey1/Rax^+	involves: ZRDCT/Ch	MGI:3809650
cx4	ey2/ey2^+ Rax^ey1/Rax^+	involves: ZRDCT/Ch	MGI:3809652

Genotype
MGI:3809662

hm1

• Allelic Composition: Rax^ey1/Rax^ey1
• Genetic Background: involves: ZRDCT/Ch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal suprachiasmatic nucleus morphology ( J:5891 )

• the nucleus suprachiasmaticus (SCN) of the mediolateral hypothalamus is abnormal due to absence of the eye and subjacent optic axons

abnormal optic nerve morphology ( J:5891 )

• the subjacent optic axons is absent

vision/eye

abnormal optic nerve morphology ( J:5891 )

• the subjacent optic axons is absent

anophthalmia ( J:5891 )

Genotype
MGI:3809647

hm2

• Allelic Composition: Rax^ey1/Rax^ey1
• Genetic Background: ZRDCT/Ch-Rax^ey1

vision/eye

abnormal lens morphology ( J:7407 )

• at the 23 to 27 somite stage, the lens placode is not as firmly adherent to the optic vesicle as in wild-type mice (C3H)

abnormal lens development ( J:5962 , J:7407 )

• at E10, the lens is improperly centered in the optic cup and lens invagination is abnormal (J:5962)

• as early as the 28 somite stage, a precocious, undersized lens cup forms unlike in wild-type mice (J:7407)

• mice exhibit a deficiency of sulfated glycosaminoglycans in the basal lamina of the optic vesicle at its interface with the lens cup during lens cup invagination (J:7407)

small lens ( J:5962 )

abnormal optic cup morphology ( J:5962 , J:7407 )

• at E10, the lens is smaller than in wild-type mice and may be improperly centered in the optic cup (J:5962)

• at the 35 to 45 somite stage, mice exhibit small optic cups surrounded by mesenchyme cells with no associated lens rudiment (J:7407)

microphthalmia ( J:229 , J:5962 )

• in 30% of mice (J:5962)

anophthalmia ( J:229 , J:5962 )

• in 70% of mice bilaterally (J:5962)

behavior/neurological

abnormal circardian behavior entrainment ( J:109897 )

• fewer mice than normal entrained to restricted wheel access

Genotype
MGI:3809650

ht3

• Allelic Composition: Rax^ey1/Rax⁺
• Genetic Background: involves: ZRDCT/Ch

vision/eye

abnormal eye morphology ( J:15549 )

• mice exhibit a higher incidence of abnormal eyes than homozygous normal mice after injection of trypan blue into their mothers during gestation

Genotype
MGI:3809652

cx4

• Allelic Composition: ey2/ey2⁺; Rax^ey1/Rax⁺
• Genetic Background: involves: ZRDCT/Ch

vision/eye

abnormal eye morphology ( J:15549 )

• mice exhibit a higher incidence of abnormal eyes than homozygous normal mice after injection of trypan blue into their mothers during gestation