All Phenotypes f MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	f/f	FL/1ReJ	MGI:3579259
hm2	f/f	involves: CBA/St	MGI:4835052
hm3	f/f	Not Specified	MGI:2174733
cx4	f/f Kit^W/Kit⁺	FL/1Re-Kit^W/J	MGI:4849372
cx5	f/f⁺ Kit^W/Kit⁺	FL/1Re-Kit^W/J	MGI:4849373
cx6	Espn^je/? f/f Hps6^ru/Hps6^ru	JE/LeJ	MGI:4437009

Allelic Composition	f/f
Genetic Background	FL/1ReJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation (4 available); any f mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

impaired hematopoiesis ( J:5654 )

• peak numbers of embryonic erythroid colony forming units only about 50% normal numbers in the liver

decreased erythrocyte cell number ( J:24610 )

• although red cell counts are significantly reduced at birth they achieve near normal levels by 7 days of age

decreased hematocrit ( J:24610 )

• at birth the hematocrit is significantly lower (31.5 versus 43.4 in controls) but hematocrit reaches normal levles by 7 days of age

decreased mean corpuscular volume ( J:24610 )

• significantly smaller volumes at birth but normal by 7 days of age

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:5591 )

• delta aminolaevulinate synthetase activity in embryonic day 16 reticulocytes on a per cell basis is reduced to 53% of that of wild-type controls, and the activity in liver at embryonic day 13-14 is also reduced but to a lesser degree

• delta aminolaevulinate dehydratase activity in embryonic day 17-18 reticulocytes on a per cell basis is appriximately half of that in wild-type controls

growth/size/body

decreased body weight ( J:24610 )

• slight reduction in body weight from birth through 60 days of age in both males and females

pigmentation

white spotting ( J:24610 )

• white pigment covers an average of 22.9% and 23.6% of the ventrum in females and males respectively

integument

white spotting ( J:24610 )

• white pigment covers an average of 22.9% and 23.6% of the ventrum in females and males respectively

Allelic Composition	f/f
Genetic Background	involves: CBA/St

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation (4 available); any f mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:164714 )

• early postnatal depletion of homozygous animals

hematopoietic system

anemia ( J:14979 , J:164714 )

• first evident at embryonic day 12 (J:14979)

hypochromic anemia ( J:164714 )

• although the mean red blood cell size is normal, the hemoglobin concentration is reduced, there are fewer red blood cells and this transitory anemia is most significant embryonically and at birth then wanes during the first few weeks of life

decreased mean corpuscular hemoglobin ( J:164714 )

increased siderocyte number ( J:14979 )

• the majority of red blood cells in newborns are siderocytes, which are incompletely haemoglobinized as evidenced by faint color and weak stain uptake

• the percentage of siderocytes decreases from 80% at birth to approximately 40% at 1 week of age and stabilizes at approximately 3% by 3 weeks of age persisting at this higher than normal level in the adult

reticulocytosis ( J:164714 )

• striking reticulocytosis at birth and reticulocyte count remains high at 13 days of age but decreases by 3 weeks of age as the anemia resolves

integument

pallor ( J:14979 )

• homozygotes are recognizably paler than normal from embryonic day 16 onward and most can be identified this way as early as embryonic day 15

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:12951 )

• death rate in the first 3 to 4 weeks after birth is about 4 times normal

limbs/digits/tail

caudal vertebral fusion ( J:13090 )

• flexure due to unilateral fusions of successive vertebrae

• first appears around E14

kinked tail ( J:12951 )

• 1-5 permanent angles in tail

• sometimes curves and spirals instead of sharp angles

• tails can occasionally be nearly normal

skeleton

abnormal vertebrae morphology ( J:13090 )

abnormal intervertebral disk development ( J:13090 )

• abnormal development

• fibrous pad sometimes fails to develop or does not develop on one side

vertebral fusion ( J:13090 )

• fusions seen in caudal vertebrae also seen throughout the vertebral column

caudal vertebral fusion ( J:13090 )

• flexure due to unilateral fusions of successive vertebrae

• first appears around E14

hematopoietic system

abnormal definitive hematopoiesis ( J:13598 )

• delayed maturation of committed erythroid stem cells

• adults with a poor response to hemopoietic stress

anemia ( J:12951 , J:13090 )

• anemia at E14 through birth (J:13090)

• hematopoesis problem in the liver (J:13090)

• anemia becomes less severe after E16 when hematopoetic function of bone marrow begins (J:13090)

• recovery from anemia in the first 2 weeks of life (J:13090)

hypochromic microcytic anemia ( J:13598 )

• transitory hypochromic and microcytic anemia

decreased erythrocyte cell number ( J:13090 )

• reduced RBC counts from E14 through birth

• adult RBC counts are normal

homeostasis/metabolism

abnormal iron homeostasis ( J:13598 )

• defective heme synthesis

growth/size/body

abnormal head morphology ( J:12951 )

• sometimes there is a dorsal enlargement of the head in front of the ears

decreased body size ( J:13090 )

• smaller size at birth and through adulthood

vision/eye

eyelids fail to open ( J:12951 )

• one or both eyes sometimes remain closed

pigmentation

belly spot ( J:13598 )

embryo

abnormal neural tube morphology ( J:13090 )

• a minority of homozygotes assessed during embryonic development are found to have irregular lumen shape, longitudinal waves or angles of the tube, or locally doubled neural tube

abnormal notochord morphology ( J:13090 )

• a minority of homozygotes assessed during embryonic development are found to have ventral swelling of the notochord, dorsal projections, bifurcate notochord, or other morphological abnormalities in the notochord

nervous system

abnormal neural tube morphology ( J:13090 )

• a minority of homozygotes assessed during embryonic development are found to have irregular lumen shape, longitudinal waves or angles of the tube, or locally doubled neural tube

integument

belly spot ( J:13598 )

Allelic Composition	f/f Kit^W/Kit⁺
Genetic Background	FL/1Re-Kit^W/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation (4 available); any f mutation (4 available)
Kit^W mutation (10 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:24610 )

• although slightly reduced in body weight relative to controls this is less severe than in flexed-tail homozygotes wildtype at the Kit locus

hematopoietic system

abnormal erythrocyte cell number ( J:24610 )

• the reduction in erythrocyte cell number at birth is less severe than in flex-tail homozygotes that are wildtype at the Kit locus and by 7 days of age the count is higher than normal and this persists

decreased hematocrit ( J:24610 )

• decreased at birth, but closer to normal values than in flexed-tail homozgyotes that are wildtype at the Kit locus

decreased mean corpuscular volume ( J:24610 )

• from birth onward more severe decrease in erythrocyte volume than in flexed-tail homozygotes wildtype at the Kit locus

pigmentation

white spotting ( J:24610 )

• the amount of white pigmentation is greater than the sum of the white pigmentation of the distinct mutants, with females having an average of 54.7% white on the ventrum and males having an average of 59.7%

integument

white spotting ( J:24610 )

Allelic Composition	f/f⁺ Kit^W/Kit⁺
Genetic Background	FL/1Re-Kit^W/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation (4 available); any f mutation (4 available)
Kit^W mutation (10 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

white spotting ( J:24610 )

• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively

integument

white spotting ( J:24610 )

• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively

Allelic Composition	Espn^je/? f/f Hps6^ru/Hps6^ru
Genetic Background	JE/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espn^je mutation (2 available); any Espn mutation (38 available)
f mutation (4 available); any f mutation (4 available)
Hps6^ru mutation (3 available); any Hps6 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mast cell degranulation ( J:37255 )

• although the rate and extent of mast cell degranulation when triggered by GTPgammaS is not significantly abnormal, the cell membrane capacitance changes of mast cells, reflective of exoctyosis, show approximately three times more transient fusion events than normal and the dwell time of the transient fusion events is increased

hematopoietic system

abnormal mast cell degranulation ( J:37255 )

cellular

abnormal mast cell degranulation ( J:37255 )

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