All Phenotypes Prss8<fr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prss8^fr
frizzy
MGI:1856875

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prss8^fr/Prss8^fr	involves: DBA * STOCK Tyr^c-ch Oca2^p Myo7a^sh1	MGI:3770129
ht2	Prss8^fr/Prss8^tm1.1Hum	involves: 129/Sv * FS/EiJ	MGI:4453213
cx3	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}	involves: 129P2/OlaHsd * DBA	MGI:5440273
cx4	Prss8^fr/Prss8⁺ Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}	involves: 129P2/OlaHsd * DBA	MGI:5440274
cx5	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺	involves: 129P2/OlaHsd * DBA	MGI:5440275
cx6	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * DBA	MGI:5440272
cx7	Prss8^fr/Prss8^fr Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * DBA	MGI:5440271
cx8	Oat^rhg/Prss8^fr	involves: AKR/J * C57BL/6JEi * FS/EiJ	MGI:6162250

Allelic Composition	Prss8^fr/Prss8^fr
Genetic Background	involves: DBA * STOCK Tyr^c-ch Oca2^p Myo7a^sh1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat appearance ( J:92 )

• Background Sensitivity: in some outcrosses, abnormal coat appearance was difficult to identify in subsequent F2 mice

• the coat is short and rough from first appearance until 6-7 weeks of age

• between 6 and 7 weeks of age fur may appear normal

• much older mice have a short and thin coat

abnormal hair growth ( J:92 )

short hair ( J:92 )

sparse hair ( J:92 )

rough coat ( J:92 )

disheveled coat ( J:92 )

abnormal hair shaft morphology ( J:92 )

abnormal hair medulla ( J:92 )

• histology shows septa between air-spaces are thicker, significantly reducing the expected size of the air spaces

abnormal vibrissa morphology ( J:92 )

curly vibrissae ( J:92 )

• noticeable by 1-2 days of age

Allelic Composition	Prss8^fr/Prss8^tm1.1Hum
Genetic Background	involves: 129/Sv * FS/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)
Prss8^tm1.1Hum mutation (0 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:159896 )

• body mass is approximately 85% of normal body size at 10 days of age

integument

sparse hair ( J:159896 )

abnormal hair follicle morphology ( J:159896 )

underdeveloped hair follicles ( J:159896 )

decreased hair follicle number ( J:159896 )

• there are fewer hair follicles and these appear immature and disorganized

curly vibrissae ( J:159896 )

• evident by 10 days of age

abnormal epidermis stratum corneum morphology ( J:159896 )

• skin sections from 10 day old pups shows disorganized compacted stratum coreum that is occassionally detached from the stratum granulosum

dry skin ( J:159896 )

Allelic Composition	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)
Spint2^{Gt(KST272)Byg} mutation (0 available); any Spint2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:188121 )

• many mice survive to term unlike mutant mice carrying at least 1 wild-type allele of Prss8

embryo

embryo phenotype ( J:188121 )

N	• almost complete rescue of neural tube closure and placental differentiation defects seen in mice homozygous for Spint2^{Gt(KST272)Byg} and heterozygous Prss8^fr

nervous system

exencephaly ( J:188121 )

• in 5% of embryos after E9.5

Allelic Composition	Prss8^fr/Prss8⁺ Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:188121 )

• no embryos are detected at E9.5-E11.5

Allelic Composition	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:188121 )

N	• expected numbers are found at term unlike mutant mice wild-type for St14

embryo

embryo phenotype ( J:188121 )

N	• complete rescue of neural tube closure and placental differentiation defects seen in mice homozygous for Spint2^{Gt(KST272)Byg} and heterozygous Prss8^fr

Allelic Composition	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188121 )

embryo

spina bifida ( J:188121 )

abnormal placenta morphology ( J:188121 )

• placental differentiation defects

limbs/digits/tail

curly tail ( J:188121 )

nervous system

spina bifida ( J:188121 )

exencephaly ( J:188121 )

Allelic Composition	Prss8^fr/Prss8^fr Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:188121 )

• many mice survive to term unlike mutant mice carrying at least 1 wild-type allele of Prss8

embryo

embryo phenotype ( J:188121 )

N	• no obvious developmental abnormalities are detected between E11.5 and E13.5 • complete rescue of placental labyrinth defects seen in mice homozygous for Spint1^tm1Bug alone

integument

abnormal coat appearance ( J:188121 )

• outwardly indistinguishable from littermates homozygous for Prss8^fr alone at up to 1 year of age

Allelic Composition	Oat^rhg/Prss8^fr
Genetic Background	involves: AKR/J * C57BL/6JEi * FS/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oat^rhg mutation (1 available); any Oat mutation (21 available)
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:213842 )

• double heterozygotes complement, having normal vibrissae, fur, and body size

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24