All Phenotypes Prss8<fr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prss8^fr
frizzy
MGI:1856875

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prss8^fr/Prss8^fr	involves: DBA * STOCK Tyr^c-ch Oca2^p Myo7a^sh1	MGI:3770129
ht2	Prss8^fr/Prss8^tm1.1Hum	involves: 129/Sv * FS/EiJ	MGI:4453213
cx3	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}	involves: 129P2/OlaHsd * DBA	MGI:5440273
cx4	Prss8^fr/Prss8⁺ Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}	involves: 129P2/OlaHsd * DBA	MGI:5440274
cx5	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺	involves: 129P2/OlaHsd * DBA	MGI:5440275
cx6	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * DBA	MGI:5440272
cx7	Prss8^fr/Prss8^fr Spint1^tm1Bug/Spint1^tm1Bug	involves: 129S6/SvEvTac * DBA	MGI:5440271
cx8	Oat^rhg/Prss8^fr	involves: AKR/J * C57BL/6JEi * FS/EiJ	MGI:6162250

Allelic Composition	Prss8^fr/Prss8^fr
Genetic Background	involves: DBA * STOCK Tyr^c-ch Oca2^p Myo7a^sh1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat appearance ( J:92 )

• Background Sensitivity: in some outcrosses, abnormal coat appearance was difficult to identify in subsequent F2 mice

• the coat is short and rough from first appearance until 6-7 weeks of age

• between 6 and 7 weeks of age fur may appear normal

• much older mice have a short and thin coat

abnormal hair growth ( J:92 )

short hair ( J:92 )

sparse hair ( J:92 )

rough coat ( J:92 )

disheveled coat ( J:92 )

abnormal hair shaft morphology ( J:92 )

abnormal hair medulla ( J:92 )

• histology shows septa between air-spaces are thicker, significantly reducing the expected size of the air spaces

abnormal vibrissa morphology ( J:92 )

curly vibrissae ( J:92 )

• noticeable by 1-2 days of age

Allelic Composition	Prss8^fr/Prss8^tm1.1Hum
Genetic Background	involves: 129/Sv * FS/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)
Prss8^tm1.1Hum mutation (0 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:159896 )

• body mass is approximately 85% of normal body size at 10 days of age

integument

sparse hair ( J:159896 )

abnormal hair follicle morphology ( J:159896 )

underdeveloped hair follicles ( J:159896 )

decreased hair follicle number ( J:159896 )

• there are fewer hair follicles and these appear immature and disorganized

curly vibrissae ( J:159896 )

• evident by 10 days of age

abnormal epidermis stratum corneum morphology ( J:159896 )

• skin sections from 10 day old pups shows disorganized compacted stratum coreum that is occassionally detached from the stratum granulosum

dry skin ( J:159896 )

Allelic Composition	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)
Spint2^{Gt(KST272)Byg} mutation (0 available); any Spint2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:188121 )

• many mice survive to term unlike mutant mice carrying at least 1 wild-type allele of Prss8

embryo

embryo phenotype ( J:188121 )

N	• almost complete rescue of neural tube closure and placental differentiation defects seen in mice homozygous for Spint2^{Gt(KST272)Byg} and heterozygous Prss8^fr

nervous system

exencephaly ( J:188121 )

• in 5% of embryos after E9.5

Allelic Composition	Prss8^fr/Prss8⁺ Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg}
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:188121 )

• no embryos are detected at E9.5-E11.5

Allelic Composition	Prss8^fr/Prss8^fr Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} St14^tm1Bug/St14⁺
Genetic Background	involves: 129P2/OlaHsd * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:188121 )

N	• expected numbers are found at term unlike mutant mice wild-type for St14

embryo

embryo phenotype ( J:188121 )

N	• complete rescue of neural tube closure and placental differentiation defects seen in mice homozygous for Spint2^{Gt(KST272)Byg} and heterozygous Prss8^fr

Allelic Composition	Prss8^fr/Prss8⁺ Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:188121 )

embryo

spina bifida ( J:188121 )

abnormal placenta morphology ( J:188121 )

• placental differentiation defects

limbs/digits/tail

curly tail ( J:188121 )

nervous system

spina bifida ( J:188121 )

exencephaly ( J:188121 )

Allelic Composition	Prss8^fr/Prss8^fr Spint1^tm1Bug/Spint1^tm1Bug
Genetic Background	involves: 129S6/SvEvTac * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:188121 )

• many mice survive to term unlike mutant mice carrying at least 1 wild-type allele of Prss8

embryo

embryo phenotype ( J:188121 )

N	• no obvious developmental abnormalities are detected between E11.5 and E13.5 • complete rescue of placental labyrinth defects seen in mice homozygous for Spint1^tm1Bug alone

integument

abnormal coat appearance ( J:188121 )

• outwardly indistinguishable from littermates homozygous for Prss8^fr alone at up to 1 year of age

Allelic Composition	Oat^rhg/Prss8^fr
Genetic Background	involves: AKR/J * C57BL/6JEi * FS/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oat^rhg mutation (1 available); any Oat mutation (19 available)
Prss8^fr mutation (13 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:213842 )

• double heterozygotes complement, having normal vibrissae, fur, and body size

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