All Phenotypes Ctsl<fs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctsl^fs
furless
MGI:1856878

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsl^fs/Ctsl^fs	involves: C57BL/6 * FSB/GnEi	MGI:2450407
hm2	Ctsl^fs/Ctsl^fs	involves: C57BL/6 * unpedigreed stock	MGI:2175822

Allelic Composition	Ctsl^fs/Ctsl^fs
Genetic Background	involves: C57BL/6 * FSB/GnEi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsl^fs mutation (1 available); any Ctsl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:81950 )

• 18% of tubules were atrophic, corresponding with a 12 fold increase in atrophy

decreased testis weight ( J:81950 )

• although males are fertile, a 25% weight reduction was observed in mice at 110 and 120 days of age relative to age matched control mice

reproductive system

abnormal seminiferous tubule morphology ( J:81950 )

• 18% of tubules were atrophic, corresponding with a 12 fold increase in atrophy

decreased testis weight ( J:81950 )

• although males are fertile, a 25% weight reduction was observed in mice at 110 and 120 days of age relative to age matched control mice

abnormal spermatogenesis ( J:81950 )

• 16% reduction in formation of preloptotene spermatocytes in non-atrophic tubules

• 25% reduction of complete differentiation of preloptotene spermatocytes into pachytene spermatocytes in non-atrophic tubules

Allelic Composition	Ctsl^fs/Ctsl^fs
Genetic Background	involves: C57BL/6 * unpedigreed stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsl^fs mutation (1 available); any Ctsl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:5217 )

• incomplete penetrance; viability up to weaning age of furless mice is considerably reduced, but survivors are fertile; heterozygotes have normal reproductive fitness and radiation sensitivity

integument

alopecia ( J:15332 )

• age of onset is 19 days, beginning at the head and progressing toward the tail region of the back

• a new coat starts to grow at age 28 - 30 days

• mature homozygous mice are always partially devoid of hair

absent vibrissae ( J:15332 )

• vibrissae fail to penetrate the epidermis at 2 days after birth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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