Phenotypes associated with this allele

• Allele Symbol: Mfsd12^gr
• Allele Name: grizzled
• Allele ID: MGI:1856888
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfsd12^gr/Mfsd12^gr	involves: A * STOCK fz	MGI:2676345
cx2	Ap3d1^mh Mfsd12^+/Ap3d1^+ Mfsd12^gr	STOCK Mfsd12^gr +/+ Ap3d1^mh/J	MGI:3765903

Genotype
MGI:2676345

hm1

• Allelic Composition: Mfsd12^gr/Mfsd12^gr
• Genetic Background: involves: A * STOCK fz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:11987 )

• mortality occurs at all stages with loss of 50-60% of mutants

postnatal lethality, incomplete penetrance ( J:11987 )

• some mutants survive to maturity

• more females than males survive

prenatal lethality, incomplete penetrance ( J:11987 )

• some survive to birth

• cranial-facial defects commonly seen may contribute to mortality

pigmentation

absent coat pigmentation ( J:24769 )

• on a non-agouti background hairs on the ears and genitalia normally yellow are white

diluted coat color ( J:11987 )

• dilutes yellow pigment (phaeomelanin)

• agouti mice look like chinchilla (A/A;c^ch/c^ch)

growth/size/body

abnormal postnatal growth/weight/body size ( J:11987 )

abnormal body weight ( J:11987 )

• weight is 25% less than normal at birth and remains 10-20% below weight of normal littermates

decreased body size ( J:11987 )

• reduced body size

• 20-30% smaller than normal littermates at birth

• 10% smaller than normal littermates as adults

decreased body weight ( J:11987 )

• weight data between 2 and 6 weeks of age show females are 75-80% of normal weight; males are 90-95% of normal weight

skeleton

abnormal skeleton morphology ( J:11987 )

abnormal craniofacial bone morphology ( J:11987 )

• commom among E16-18 fetuses; not seen among pups after birth

abnormal cranium morphology ( J:11987 )

abnormal jaw morphology ( J:11987 )

• most frequent abnormaity among E16-18 fetuses; not seen among pups after birth

craniofacial

abnormal craniofacial bone morphology ( J:11987 )

• commom among E16-18 fetuses; not seen among pups after birth

abnormal cranium morphology ( J:11987 )

abnormal jaw morphology ( J:11987 )

• most frequent abnormaity among E16-18 fetuses; not seen among pups after birth

reproductive system

abnormal ovulation ( J:11987 )

♀

decreased ovulation rate ( J:11987 )

♀ • although low compared to normal, ovulation rate is consistent with smaller size of mutant mice

limbs/digits/tail

abnormal tail morphology ( J:11987 )

kinked tail ( J:11987 )

• occasionally seen

integument

absent coat pigmentation ( J:24769 )

• on a non-agouti background hairs on the ears and genitalia normally yellow are white

diluted coat color ( J:11987 )

• dilutes yellow pigment (phaeomelanin)

• agouti mice look like chinchilla (A/A;c^ch/c^ch)

Genotype
MGI:3765903

cx2

• Allelic Composition: Ap3d1^mh Mfsd12⁺/Ap3d1⁺ Mfsd12^gr
• Genetic Background: STOCK Mfsd12^gr +/+ Ap3d1^mh/J

nervous system

abnormal brain wave pattern ( J:96307 )

• electrocorticograms of mocha heterozygotes show occasional brief bursts of lower voltage theta waves, which are a less pronounced abnormality than in homozygotes