All Phenotypes Tpst2<grt> MGI Mouse

• contains clustered and unusual chromophobic cells unreative to antisera against anterior pituitary hormones

enlarged adenohypophysis ( J:20343 )

• before 13 weeks of age tubules of mutant mice are smaller than those of control mice but are comparable by 26 weeks of age

small seminiferous tubules ( J:137590 )

• before 13 weeks of age tubules of mutant mice are smaller than those of control mice

decreased testis weight ( J:137590 )

• weight of testes from mutant mice was significantly less than age-matched control mice until 8 weeks of age, being comparable at 13-26 weeks

• the severe primary hypothyroidism correlates with loss of tyrosylprotein sulfotransferase activity

postnatal growth retardation ( J:20343 )

• there is normal growth until about 2 weeks of age when growth is suppressed

• during pubertal growth, from 3 weeks to a month of age, mutant mice weigh significantly less than control siblings

• the visible size differences between mutant mice and controls gradually diminishes until by one year of age the two are indistinguishable

• mice exhibit low concentrations of serum T3 and T4

• elevation in circulating TSH levels in response to low T3 and T4 levels shows the pituitary is normal

• a tri-iodothyronine supplement is effective in shortening the early growth pause and reactivating the suppressed pubertal growth phase

abnormal growth hormone level ( J:20343 )

• the expected increase in pituitary GH seen at puberty is delayed