Phenotypes associated with this allele

• Allele Symbol: htd
• Allele Name: hair-thyroid deficient
• Allele ID: MGI:1856907
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	htd/htd	C3H/HeJ-htd/J	MGI:5588805

Genotype
MGI:5588805

hm1

• Allelic Composition: htd/htd
• Genetic Background: C3H/HeJ-htd/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat appearance ( J:68094 )

abnormal hair growth ( J:68094 )

• feeding dessicated thyroid powder at weaning does not improve hair growth

hairless ( J:68094 )

• by weaning there is progressive hairloss from face to tail

• some mutants are and remain hairless after weaning; less affected mutant mice show sporadic hair regrowth

abnormal skin condition ( J:68094 )

• by 8 days of age the skin mutant mice is rubbery

reproductive system

reduced fertility ( J:68094 )

mortality/aging

lethality, incomplete penetrance ( J:68094 )

• feeding dessicated thyroid powder at weaning does improve viability

growth/size/body

decreased body size ( J:68094 )

• compared with wild-type siblings

• feeding dessicated thyroid powder at weaning does not improve growth parameters

decreased body weight ( J:68094 )

• at 15 days of age mutant mice weigh significantly less than wild-type siblings and are half the weight of wild-type sex-matched siblings by 43 days of ages

• feeding dessicated thyroid powder at weaning does not affect weight

homeostasis/metabolism

decreased circulating thyroxine level ( J:68094 )

decreased circulating triiodothyronine level ( J:68094 )

increased circulating corticosterone level ( J:68094 )

♂ • mutant males had twice the amount compared with wild-type siblings; values for mutant females are normal

endocrine/exocrine glands

abnormal submandibular gland morphology ( J:68094 )

• mutant males have fewer tubules than control males; mutant females have more tubules than control females

abnormal thyroid follicular cell morphology ( J:68094 )

• histological analyses showed the follicular cell lining to be atypically flat

digestive/alimentary system

abnormal submandibular gland morphology ( J:68094 )

• mutant males have fewer tubules than control males; mutant females have more tubules than control females