Phenotypes associated with this allele

• Allele Symbol: Utp14b^jsd
• Allele Name: juvenile spermatogonial depletion
• Allele ID: MGI:1856924
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Utp14b^jsd/Utp14b^jsd	involves: C3H/HeJ * C57BL/6J	MGI:3051983
hm2	Utp14b^jsd/Utp14b^jsd	involves: C57BL/6J	MGI:2657236

Genotype
MGI:3051983

hm1

• Allelic Composition: Utp14b^jsd/Utp14b^jsd
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:91782 )

♂ • testes weight is significantly reduced at 6 weeks of age

reproductive system

azoospermia ( J:91782 )

♂ • no sperm are found in the testes

decreased testis weight ( J:91782 )

♂ • testes weight is significantly reduced at 6 weeks of age

male infertility ( J:91782 )

♂ • males are infertile

cellular

azoospermia ( J:91782 )

♂ • no sperm are found in the testes

Genotype
MGI:2657236

hm2

• Allelic Composition: Utp14b^jsd/Utp14b^jsd
• Genetic Background: involves: C57BL/6J

reproductive system

reproductive system phenotype ( J:9278 )

N • despite the male testicular hypoplasia, female ovarian mass is consistently normal

decreased testis weight ( J:9278 )

♂ • throughout life the testis weight is greatly reduced, and the highest mean testis weight of approximately 32 mg is found at 6 weeks of age

testis hypoplasia ( J:9278 )

♂

abnormal spermatogenesis ( J:1815 , J:9278 )

♂ • transplantation of C57BL/6J seminiferous tubules into the testes of homozygous mutants yields differentiation of type A spermatogonia into spermatids, but transplantation of seminiferous tubules from homozygous mutants into dominant spotting/viable dominant spotting compound heterozygotes, which lack germ cells, fail to produce mature spermatids indicating a defect in the intratubular environment (J:1815)

♂ • at 3 weeks of age histology shows occasional testicular tubules deficient in spermatogonial and primary spermatocytes, at 5 weeks of age some tubules hace predominantly Sertoli cells with a few spermatogonial cells and other tubules have maturing spermatids, at 6 to 7 weeks of age small numbers of sperm with normal morphology and good motility are found, but sperm are not found after 8 weeks of age and after 9 weeks of age the testis are devoid of spermatogenesis with small diameter tubules populated predominantly by Sertoli cells and type A spermatogonial cells (J:9278)

♂ • DNA synthesis in testes as assessed by tritiated thymidine uptake is readily detectable at 4.5 weeks of age, but only at low frequency at 7.5 weeks of age (J:9278)

endocrine/exocrine glands

decreased testis weight ( J:9278 )

♂ • throughout life the testis weight is greatly reduced, and the highest mean testis weight of approximately 32 mg is found at 6 weeks of age

testis hypoplasia ( J:9278 )

♂

growth/size/body

growth/size/body region phenotype ( J:9278 )

N • normal body weight at all ages from 3 weeks to a year

nervous system

failure of neuromuscular synapse postsynaptic differentiation ( J:9278 )

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:9278 )

• although testosterone levels are within normal limits, serum follicle stimulating hormone levels in males are significantly higher than normal as early as 4 to 6 weeks of age and taper by 52 weeks of age