Phenotypes associated with this allele

• Allele Symbol: lgl
• Allele Name: legless
• Allele ID: MGI:1856934
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	lgl/lgl	involves: C3H * C57BL/6	MGI:5629847
cx2	lgl/lgl^+ Sp8^tm1Smb/Sp8^+	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6	MGI:2684127

Genotype
MGI:5629847

hm1

• Allelic Composition: lgl/lgl
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:9298 )

• may not develop

ectrodactyly ( J:9298 )

• of preaxial digits

abnormal forelimb morphology ( J:9298 )

• mutant mice lack any number of digits and the radius and carpus may be rudimentary or missing

abnormal radius morphology ( J:9298 )

• missing or rudimentary in some mutant mice

abnormal hindlimb morphology ( J:9298 )

• 90% of mutant mice appear legless because only the femur develops

nervous system

abnormal embryonic neuroepithelium morphology ( J:9298 )

• cell disorganization and necrosis of the anterior aspect is commonly seen in 20-somite embryo

abnormal brain development ( J:9298 )

• abnormal brain shape is common in newborns

hydrocephaly ( J:9298 )

• involves the lateral ventricles of the brain of many newborns

abnormal cerebral hemisphere morphology ( J:9298 )

• anterior structures are abnormal and distinctive hemispheric shape is absent

abnormal cerebral cortex morphology ( J:9298 )

• 46% of mutant mice have hemorrhagic protrusions from the cerebral cortex, seen externally as "bumps" between the eyes

abnormal olfactory lobe morphology ( J:9298 )

• abnormal or missing lobes are common

craniofacial

abnormal craniofacial morphology ( J:9298 )

• 40% of mutant mice have cleft lip and/or cleft palate

cleft upper lip ( J:9298 )

abnormal palate morphology ( J:9298 )

cleft palate ( J:9298 )

thin nasal septum ( J:9298 )

• thinning of the nasal septum is commonly seen in newborns

facial cleft ( J:9298 )

growth/size/body

cleft upper lip ( J:9298 )

abnormal palate morphology ( J:9298 )

cleft palate ( J:9298 )

thin nasal septum ( J:9298 )

• thinning of the nasal septum is commonly seen in newborns

facial cleft ( J:9298 )

skeleton

abnormal carpal bone morphology ( J:9298 )

• may not develop

abnormal radius morphology ( J:9298 )

• missing or rudimentary in some mutant mice

digestive/alimentary system

abnormal palate morphology ( J:9298 )

cleft palate ( J:9298 )

respiratory system

thin nasal septum ( J:9298 )

• thinning of the nasal septum is commonly seen in newborns

embryo

abnormal embryonic neuroepithelium morphology ( J:9298 )

• cell disorganization and necrosis of the anterior aspect is commonly seen in 20-somite embryo

mortality/aging

neonatal lethality, complete penetrance ( J:9298 )

Genotype
MGI:2684127

cx2

• Allelic Composition: lgl/lgl⁺; Sp8^tm1Smb/Sp8⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

mortality/aging

perinatal lethality ( J:86196 )

• die within 24 hours of birth

craniofacial

abnormal craniofacial morphology ( J:86196 )

limbs/digits/tail

adactyly ( J:86196 )

abnormal forelimb morphology ( J:86196 )

• abnormal radius and ulna

• absence of distal bones

• normal formation of the humerus

abnormal radius morphology ( J:86196 )

• dysplastic radius

abnormal ulna morphology ( J:86196 )

• distally truncated

abnormal hindlimb morphology ( J:86196 )

• lacked structures distal to femur

absent fibula ( J:86196 )

absent tibia ( J:86196 )

abnormal tail morphology ( J:86196 )

• exhibited by 85%

caudal vertebral fusion ( J:86196 )

• fusion of tail vertebrae

skeleton

abnormal radius morphology ( J:86196 )

• dysplastic radius

abnormal ulna morphology ( J:86196 )

• distally truncated

absent fibula ( J:86196 )

absent tibia ( J:86196 )

caudal vertebral fusion ( J:86196 )

• fusion of tail vertebrae

nervous system

incomplete rostral neuropore closure ( J:86196 )

• anterior neural tube closure defects exhibited by 85% of fetuses

exencephaly ( J:86196 )

• exhibited by 59%

encephalomeningocele ( J:86196 )

• encephaloceles observed in 26%

embryo

incomplete rostral neuropore closure ( J:86196 )

• anterior neural tube closure defects exhibited by 85% of fetuses