Phenotypes associated with this allele

• Allele Symbol: Srebf2^lop13
• Allele Name: lens opacity 13
• Allele ID: MGI:1856940
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srebf2^lop13/Srebf2^lop13	STOCK Srebf2^lop13/J	MGI:3581176
ht2	Srebf2^Gt(YTA054)Byg/Srebf2^lop13	involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J	MGI:5293677

Genotype
MGI:3581176

hm1

• Allelic Composition: Srebf2^lop13/Srebf2^lop13
• Genetic Background: STOCK Srebf2^lop13/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cataracts in Srebf2^lop13/Srebf2^lop13 mice

vision/eye

vision/eye phenotype ( J:13874 )

N • despite lens opacity, mice exhibit normal lens cortex and eye size

abnormal lens fiber morphology ( J:176249 )

• abnormalities of the lens fiber cells, such as swollen cortical fibers and bladder cells, are seen

• degeneration of lens fibers is seen

cataract ( J:13874 , J:176249 )

• mice can be identified at 3 to 4 weeks of age by a bilateral white area in the center of the lens (J:13874)

• between 4 and 10 weeks of age nuclear cataracts progress to mature cataracts (J:176249)

• by 3 months of age all mice display hypermature cataracts (J:176249)

nuclear cataract ( J:176249 )

• bilateral nuclear cataracts at P28

integument

abnormal skin condition ( J:176249 )

• develop persistent wounds of the skin in areas around the eye and on the back of the neck at 3 months of age

• once formed, wounds do not heal

homeostasis/metabolism

decreased cholesterol level ( J:176249 )

• decreased level in the lens

• however, no difference in serum cholesterol levels is detected

decreased brain cholesterol level ( J:176249 )

decreased liver cholesterol level ( J:176249 )

liver/biliary system

decreased liver cholesterol level ( J:176249 )

nervous system

decreased brain cholesterol level ( J:176249 )

Genotype
MGI:5293677

ht2

• Allelic Composition: Srebf2^{Gt(YTA054)Byg}/Srebf2^lop13
• Genetic Background: involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J

Lens abnormalities in Srebf2^{Gt(YTA054)Byg}/Srebf2^lop13 eyes

mortality/aging

prenatal lethality, incomplete penetrance ( J:176249 )

• deviation from expected numbers suggests some embryonic lethality

vision/eye

abnormal lens fiber morphology ( J:176249 )

• abnormalities of the lens fiber cells, such as swollen cortical fibers and bladder cells, are seen

• degeneration of lens fibers is seen

cataract ( J:176249 )

• at 6 weeks of age

integument

abnormal skin condition ( J:176249 )

• develop persistent wounds of the skin in areas around the eye and on the back of the neck