All Phenotypes Zbtb16<lu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zbtb16^lu
luxoid
MGI:1856943

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb16^lu/Zbtb16^lu	B10.C3-Zbtb16^lu	MGI:3042590
hm2	Zbtb16^lu/Zbtb16^lu	B6.C3-Zbtb16^Lu	MGI:3042593
hm3	Zbtb16^lu/Zbtb16^lu	B6.C3-Zbtb16^lu/J	MGI:5301113
hm4	Zbtb16^lu/Zbtb16^lu	involves: C3H/He	MGI:3042589
hm5	Zbtb16^lu/Zbtb16^lu	involves: C3H/He * C57BL/6	MGI:4457502
hm6	Zbtb16^lu/Zbtb16^lu	Not Specified	MGI:3042594
ht7	Zbtb16^lu/Zbtb16⁺	B10.C3-Zbtb16^lu	MGI:3042592
ht8	Zbtb16^lu/Zbtb16⁺	involves: C3H/He	MGI:3042591

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	B10.C3-Zbtb16^lu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

polydactyly ( J:13069 )

• preaxial polydactyly; incomplete penetrance; often an extra preaxial digit is present; up to two extra toes are seen with variable degrees of development; the second or third digit may be split

abnormal tarsal bone morphology ( J:13069 )

long fibula ( J:13069 )

short tibia ( J:13069 )

• less severe than C3H background; results in increased length of the fibula and the shank and foot are not held in the normal position

kinked tail ( J:13069 )

skeleton

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

abnormal tarsal bone morphology ( J:13069 )

long fibula ( J:13069 )

short tibia ( J:13069 )

• less severe than C3H background; results in increased length of the fibula and the shank and foot are not held in the normal position

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	B6.C3-Zbtb16^Lu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small testis ( J:89934 )

• observed in 8 month old mice; suggested to be due to loss of germ cells

reproductive system

decreased male germ cell number ( J:89934 )

• many seminiferous tubules of older mice were agametic, containing only Sertoli cells; other tubules lacked one or more germ cell generations

azoospermia ( J:89934 )

• observed in 8 month old mice

small testis ( J:89934 )

• observed in 8 month old mice; suggested to be due to loss of germ cells

cellular

decreased male germ cell number ( J:89934 )

• many seminiferous tubules of older mice were agametic, containing only Sertoli cells; other tubules lacked one or more germ cell generations

azoospermia ( J:89934 )

• observed in 8 month old mice

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	B6.C3-Zbtb16^lu/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased NK T cell number ( J:139690 )

• NK T cells are reduced by 90-99% in the thymus, spleen and liver in 4 to 8 week old mice; other lymphocyte populations in the thymus, spleen and lymph node are not affected

immune system

decreased NK T cell number ( J:139690 )

• NK T cells are reduced by 90-99% in the thymus, spleen and liver in 4 to 8 week old mice; other lymphocyte populations in the thymus, spleen and lymph node are not affected

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	involves: C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachyphalangia ( J:13069 )

• occasional preaxial reduction; hallux is reduced or absent

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

polydactyly ( J:13069 )

• preaxial polydactyly; incomplete penetrance; less frequent than on the C57BL/10 background; often an extra preaxial digit is present; up to two extra toes are seen with variable degrees of development; the second or third digit may be split

abnormal tarsal bone morphology ( J:13069 )

bowed fibula ( J:13069 )

• curved

long fibula ( J:13069 )

short tibia ( J:13069 )

• results in the curvature of the fibula and the knee and heel are brought close together

kinked tail ( J:13069 )

skeleton

brachyphalangia ( J:13069 )

• occasional preaxial reduction; hallux is reduced or absent

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

abnormal tarsal bone morphology ( J:13069 )

bowed fibula ( J:13069 )

• curved

long fibula ( J:13069 )

short tibia ( J:13069 )

• results in the curvature of the fibula and the knee and heel are brought close together

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	involves: C3H/He * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

seminiferous tubule degeneration ( J:160477 )

• dramatic germ cell loss (Sertoli Cell only tubules) even at 3 months of age

• over 50% of tubules are PCNA-negative at 8 months of age

endocrine/exocrine glands

seminiferous tubule degeneration ( J:160477 )

• dramatic germ cell loss (Sertoli Cell only tubules) even at 3 months of age

• over 50% of tubules are PCNA-negative at 8 months of age

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:5206 )

• lack of spermatogonia after 6 weeks of age; production of spermatogonia is normal at birth, then a rapid loss of germline cells occurs

male infertility ( J:5206 )

cellular

azoospermia ( J:5206 )

• lack of spermatogonia after 6 weeks of age; production of spermatogonia is normal at birth, then a rapid loss of germline cells occurs

Allelic Composition	Zbtb16^lu/Zbtb16⁺
Genetic Background	B10.C3-Zbtb16^lu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

polydactyly ( J:13069 )

• preaxial polydactyly; incomplete penetrance on hind limb only; up to two extra toes are seen with variable degrees of development

skeleton

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

Allelic Composition	Zbtb16^lu/Zbtb16⁺
Genetic Background	involves: C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

skeleton

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

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