Phenotypes associated with this allele

• Allele Symbol: Lx
• Allele Name: luxate
• Allele ID: MGI:1856944
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lx/Lx	CBA.Cg-Lx	MGI:3767992
hm2	Lx/Lx	involves: fancier's silver mouse	MGI:2175105
ht3	Lx/Lx^+	involves: fancier's silver mouse	MGI:2175106
cx4	Dh/Dh^+ Lx/Lx^+	Not Specified	MGI:3811814

Genotype
MGI:3767992

hm1

• Allelic Composition: Lx/Lx
• Genetic Background: CBA.Cg-Lx

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal umbilical artery morphology ( J:14981 )

• at day E11.5, the right umbilical artery is highly abnormal and, with the left umbilical artery, forms a ring which is often too small to allow free passage of the developing kidneys as they migrate forward

small hindlimb buds ( J:14981 )

• posterior limb buds are narrower than in wild-type mice

limbs/digits/tail

small hindlimb buds ( J:14981 )

• posterior limb buds are narrower than in wild-type mice

cardiovascular system

abnormal umbilical artery morphology ( J:14981 )

• at day E11.5, the right umbilical artery is highly abnormal and, with the left umbilical artery, forms a ring which is often too small to allow free passage of the developing kidneys as they migrate forward

Genotype
MGI:2175105

hm2

• Allelic Composition: Lx/Lx
• Genetic Background: involves: fancier's silver mouse

mortality/aging

postnatal lethality, incomplete penetrance ( J:13039 )

• some mice fail to thrive and die prior to weaning

reproductive system

abnormal reproductive system morphology ( J:13039 )

• some mice exhibit unilateral genital agenesia

limbs/digits/tail

brachypodia ( J:13039 )

abnormal digit morphology ( J:13039 )

• digit abnormalities are usually bilateral and asymmetric

• the right foot is often more severely affected than the left

oligodactyly ( J:13039 )

• some mice have as few as 3 digits per foot

polydactyly ( J:13039 )

• some mice have up to seven digits per foot

abnormal tarsal bone morphology ( J:13039 )

• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing

abnormal hindlimb morphology ( J:13039 )

• the hindlimbs below the knee appear twisted

absent tibia ( J:13039 )

renal/urinary system

abnormal kidney morphology ( J:13039 )

• some kidneys are horseshoe-shaped

enlarged kidney ( J:13039 )

• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters

hydronephrosis ( J:13039 )

• unilateral or bilateral

absent kidney ( J:13039 )

• some mice display kidney agenesis

dilated ureter ( J:13039 )

hydroureter ( J:13039 )

behavior/neurological

impaired limb coordination ( J:13039 )

• unlike wild-type mice, when mice fall they cannot control their rotation and do not land on their feet

hindlimb paresis ( J:13039 )

• mice exhibit loss of hindlimb function that is unilateral (preferentially the right hindlimb) though occassionally bilateral

• however, mice can still walk and swim albeit slower than wild-type mice

growth/size/body

decreased body size ( J:13039 )

enlarged kidney ( J:13039 )

• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters

skeleton

abnormal tarsal bone morphology ( J:13039 )

• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing

absent tibia ( J:13039 )

abnormal presacral vertebrae morphology ( J:13039 )

• reduction of presacral vertebrae

Genotype
MGI:2175106

ht3

• Allelic Composition: Lx/Lx⁺
• Genetic Background: involves: fancier's silver mouse

limbs/digits/tail

polydactyly ( J:13039 )

• mice exhibit paraxial polydactyly in hindlimbs

Genotype
MGI:3811814

cx4

• Allelic Composition: Dh/Dh⁺; Lx/Lx⁺
• Genetic Background: Not Specified

limbs/digits/tail

oligodactyly ( J:112 )

• high incidence in compound heterozygotes

absent femur ( J:112 )

• 13 of 20 adult compound heterozygotes have defective femora

absent tibia ( J:112 )

• 19 of 20 adult compound heterozygotes lack tibiae and the one with tibiae is hemimelic

skeleton

absent femur ( J:112 )

• 13 of 20 adult compound heterozygotes have defective femora

absent tibia ( J:112 )

• 19 of 20 adult compound heterozygotes lack tibiae and the one with tibiae is hemimelic

abnormal pubis morphology ( J:112 )

• 2 of 20 adult compound heterozygotes have pubic bone defects