All Phenotypes Lx MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lx/Lx	CBA.Cg-Lx	MGI:3767992
hm2	Lx/Lx	involves: fancier's silver mouse	MGI:2175105
ht3	Lx/Lx⁺	involves: fancier's silver mouse	MGI:2175106
cx4	Dh/Dh⁺ Lx/Lx⁺	Not Specified	MGI:3811814

Allelic Composition	Lx/Lx
Genetic Background	CBA.Cg-Lx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lx mutation (1 available); any Lx mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal umbilical artery morphology ( J:14981 )

• at day E11.5, the right umbilical artery is highly abnormal and, with the left umbilical artery, forms a ring which is often too small to allow free passage of the developing kidneys as they migrate forward

small hindlimb buds ( J:14981 )

• posterior limb buds are narrower than in wild-type mice

limbs/digits/tail

small hindlimb buds ( J:14981 )

• posterior limb buds are narrower than in wild-type mice

cardiovascular system

abnormal umbilical artery morphology ( J:14981 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:13039 )

• some mice fail to thrive and die prior to weaning

reproductive system

abnormal reproductive system morphology ( J:13039 )

• some mice exhibit unilateral genital agenesia

limbs/digits/tail

brachypodia ( J:13039 )

abnormal digit morphology ( J:13039 )

• digit abnormalities are usually bilateral and asymmetric

• the right foot is often more severely affected than the left

oligodactyly ( J:13039 )

• some mice have as few as 3 digits per foot

polydactyly ( J:13039 )

• some mice have up to seven digits per foot

abnormal tarsal bone morphology ( J:13039 )

• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing

abnormal hindlimb morphology ( J:13039 )

• the hindlimbs below the knee appear twisted

absent tibia ( J:13039 )

renal/urinary system

abnormal kidney morphology ( J:13039 )

• some kidneys are horseshoe-shaped

enlarged kidney ( J:13039 )

• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters

hydronephrosis ( J:13039 )

• unilateral or bilateral

absent kidney ( J:13039 )

• some mice display kidney agenesis

dilated ureter ( J:13039 )

hydroureter ( J:13039 )

behavior/neurological

impaired limb coordination ( J:13039 )

• unlike wild-type mice, when mice fall they cannot control their rotation and do not land on their feet

hindlimb paresis ( J:13039 )

• mice exhibit loss of hindlimb function that is unilateral (preferentially the right hindlimb) though occassionally bilateral

• however, mice can still walk and swim albeit slower than wild-type mice

growth/size/body

decreased body size ( J:13039 )

enlarged kidney ( J:13039 )

• mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters

skeleton

abnormal tarsal bone morphology ( J:13039 )

• the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing

absent tibia ( J:13039 )

abnormal presacral vertebrae morphology ( J:13039 )

• reduction of presacral vertebrae

Allelic Composition	Lx/Lx⁺
Genetic Background	involves: fancier's silver mouse

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lx mutation (1 available); any Lx mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:13039 )

• mice exhibit paraxial polydactyly in hindlimbs

Allelic Composition	Dh/Dh⁺ Lx/Lx⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dh mutation (1 available); any Dh mutation (1 available)
Lx mutation (1 available); any Lx mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

oligodactyly ( J:112 )

• high incidence in compound heterozygotes

absent femur ( J:112 )

• 13 of 20 adult compound heterozygotes have defective femora

absent tibia ( J:112 )

• 19 of 20 adult compound heterozygotes lack tibiae and the one with tibiae is hemimelic

skeleton

absent femur ( J:112 )

• 13 of 20 adult compound heterozygotes have defective femora

absent tibia ( J:112 )

• 19 of 20 adult compound heterozygotes lack tibiae and the one with tibiae is hemimelic

abnormal pubis morphology ( J:112 )

• 2 of 20 adult compound heterozygotes have pubic bone defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24