Phenotypes associated with this allele

• Allele Symbol: Dock7^m
• Allele Name: misty
• Allele ID: MGI:1856946
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock7^m/Dock7^m	B6.D(Cg)-Dock7^m	MGI:3582588
hm2	Dock7^m/Dock7^m	BKS.Cg-Dock7^m +/+ Lepr^db/BomTac	MGI:3841477
hm3	Dock7^m/Dock7^m	involves: DBA/J	MGI:2677402
cx4	Dock7^m/Dock7^+ Lepr^db/Lepr^+	BKS.Cg-Dock7^m +/+ Lepr^db/J	MGI:3776095

Genotype
MGI:3582588

hm1

• Allelic Composition: Dock7^m/Dock7^m
• Genetic Background: B6.D(Cg)-Dock7^m

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased white adipose tissue amount ( J:48831 )

• mice have 21% less inguinal adipose mass

abnormal brown adipose tissue mass ( J:45425 )

• appears to be completely absent in neonatal mice

growth/size/body

decreased body weight ( J:48831 )

• mutants weigh 15% less

decreased body length ( J:48831 )

• mutants are 8% shorter

hematopoietic system

decreased platelet ADP level ( J:45425 )

• platelet ADP levels are low

• however, the platelet count, and platelet serotonin and ATP levels are normal

homeostasis/metabolism

increased bleeding time ( J:45425 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
platelet storage pool deficiency		DOID:2223	OMIM:185050	J:45425

Genotype
MGI:3841477

hm2

• Allelic Composition: Dock7^m/Dock7^m
• Genetic Background: BKS.Cg-Dock7^m +/+ Lepr^db/BomTac

behavior/neurological

behavior/neurological phenotype ( J:146458 )

N • homozygous mutant and wild type control (C57BL/6J) mice exhibit similar locomotor activity; response in the tail-suspension test for depressive behavior; learning as measured by habituation of object exploration; working memory as measured using the Y maze; anxiety-like behavior in a light-dark transfer test; and preference for social familiarity/novelty

Genotype
MGI:2677402

hm3

• Allelic Composition: Dock7^m/Dock7^m
• Genetic Background: involves: DBA/J

pigmentation

diluted coat color ( J:311 )

• individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice

• coat color is not as diluted as that of homozygous dilute (Myo5a^d) or homozygous leaden (Mlph^ln) mice

variable body spotting ( J:311 )

• white tail tip with or without a white belly spot

integument

diluted coat color ( J:311 )

• coat color is not as diluted as that of homozygous dilute (Myo5a^d) or homozygous leaden (Mlph^ln) mice

• individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice

variable body spotting ( J:311 )

• white tail tip with or without a white belly spot

Genotype
MGI:3776095

cx4

• Allelic Composition: Dock7^m/Dock7⁺; Lepr^db/Lepr⁺
• Genetic Background: BKS.Cg-Dock7^m +/+ Lepr^db/J

mortality/aging

extended life span ( J:6081 )

• increased survival when totally deprived of food than wild-type controls

• Background Sensitivity: survival when deprived of food is longer rhan when in a C57BL/6 background