All Phenotypes Cpox<nct> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cpox^nct
Nakano cataract
MGI:1856966

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpox^nct/Cpox^nct	involves: BALB/cCrSlc	MGI:5488915
hm2	Cpox^nct/Cpox^nct	Not Specified	MGI:4399726
cx3	Cpox^nct/Cpox^nct Nctm1^BALB/c/Nctm1^BALB/c	involves: BALB/c * MSM	MGI:3036070
cx4	Cpox^nct/Cpox^nct Nctm2^BALB/c/Nctm2^BALB/c	involves: BALB/c * MSM	MGI:3036071

Allelic Composition	Cpox^nct/Cpox^nct
Genetic Background	involves: BALB/cCrSlc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpox^nct mutation (1 available); any Cpox mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:196645 )

• at 10 weeks

• however, mice also expression a transgene containing the endogenous gene do not develop cataracts during the 6 month observation period

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary coproporphyria		DOID:13269	OMIM:121300	J:196645

Allelic Composition	Cpox^nct/Cpox^nct
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpox^nct mutation (1 available); any Cpox mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:5481 , J:6014 )

• histological analysis shows slower than normal loss of lens cell nuclei, especially in the bow area, by 7 days of age (J:5481)

• persistence of cell nuclei in the bow area is noteable at 12-13 days of age (J:5481)

• there is a decrease in crystallin and leakage of crystallin from the lens (J:6014)

abnormal lens fiber morphology ( J:5481 )

• distal portions of many fibers swell and become hydropic

• at 20-23 days of age lens fibers are disintegrating posterior to the center of the lens with histology showing broken cell borders, many vacuoles and large swollen cells

hydropic eye lens fibers ( J:5481 )

cataract ( J:5481 )

• an opaque spot first appears in mutant mice between 16 to 22 days of age

• the whole lens is opaque by 4-5 weeks of age

Allelic Composition	Cpox^nct/Cpox^nct Nctm1^BALB/c/Nctm1^BALB/c
Genetic Background	involves: BALB/c * MSM

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpox^nct mutation (1 available); any Cpox mutation (33 available)
Nctm1^BALB/c mutation (0 available); any Nctm1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:80817 )

• decreased cataract severity

Allelic Composition	Cpox^nct/Cpox^nct Nctm2^BALB/c/Nctm2^BALB/c
Genetic Background	involves: BALB/c * MSM

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpox^nct mutation (1 available); any Cpox mutation (33 available)
Nctm2^BALB/c mutation (0 available); any Nctm2 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:80817 )

• decreased cataract severity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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