Phenotypes associated with this allele

• Allele Symbol: nd
• Allele Name: nodding
• Allele ID: MGI:1856967
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	nd/nd	129/Sv-nd	MGI:3768658

Genotype
MGI:3768658

hm1

• Allelic Composition: nd/nd
• Genetic Background: 129/Sv-nd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:24834 )

• a severe cerebellar syndrome develops by 10 days of age

ataxia ( J:24834 )

impaired limb coordination ( J:24834 )

• locomotion is impeded anddoes not improve with age

head bobbing ( J:24834 )

nervous system

abnormal cerebellum morphology ( J:24834 )

abnormal cerebellar Purkinje cell layer ( J:10974 )

abnormal Purkinje cell morphology ( J:10974 )

• cerebellar Purkinje cells have hypotrophic and incompletely compartmentalized dendrites

• a result of late maturation of Purkinge cells and development of ectopic dendritic spines

abnormal Purkinje cell dendrite morphology ( J:10974 )

• dendrites are hypotrophic and incompletely compartmentalized

• not innervated in 4 to 5 week old mice; spines are innervated in 6-14 month old mice

abnormal cerebellar granule cell morphology ( J:24834 )

• Nissl staining shows mild granule cell degeneration

small cerebellum ( J:24834 )

• normal foliation and lamination

• slightly smaller than normal

delayed CNS synapse formation ( J:10974 )

abnormal synaptic bouton morphology ( J:10974 )

• abnormally large presynaptic elements

abnormal nervous system electrophysiology ( J:10974 )

abnormal nerve conduction ( J:10974 )

• spines of proximal dendritic branches are not innervated in 4 to 5 week old mice; but are in mice 6 to 14 months of age

muscle

muscle hypertonia ( J:24834 )

• mice become spastic, especially in hind limbs